Introduction: Tumor hypoxia is acknowledged as a major factor of resistance of solid tumors to treatment. Improving tumor oxygenation at the time of treatment could lead to an improved response to both chemotherapy and radiotherapy. Variations in T1 and T2* are potentially valuable MRI tools to follow changes in tumor oxygenation. T2* is sensitive to the relative Hb/HbO2 ratio in vessel , while...

Abstract Ongoing efforts in the field of Cancer Neuroscience seek to improve understanding neuron-cancer interactions and their effects on tumor progression. In glioma, synaptic neuronal input cells drives progression invasion. Even though have been described brain metastases extracranial tumors as well, mechanisms action between nervous system are incompletely understood. Systematic transcript...

By mapping the distribution of targeted plasmonic nanoparticles (NPs), photoacoustic (PA) imaging offers the potential to detect the pathologies in the early stages. However, optical absorption of the endogenous chromophores in the background tissue significantly reduces the contrast resolution of photoacoustic imaging. Previously, we introduced MPA imaging - a synergistic combination of magnet...

The present study aimed to evaluate the feasibility of performing carbogen gas-challenge blood oxygen level-dependent (BOLD) magnetic resonance imaging (MRI) measurements in patients with hepatocellular carcinoma (HCC). A total of 25 patients with HCC underwent T2* mapping derived from multi-echo gradient-recalled echo imaging prior to and following breathing carbogen (95% O2 and 5% CO2) for 10...

High-resolution array comparative genomic hybridization (aCGH) provides exon-level mapping of DNA aberrations in cells or tissues. Such aberrations are central to carcinogenesis and, in many cases, central to targeted therapy of the cancers. Some of the aberrations are sporadic, one-of-a-kind changes in particular tumor samples; others occur frequently and reflect common themes in cancer biolog...

BACKGROUND In the staging of endometrial cancer, controversy remains regarding the role of sentinel lymph node mapping compared with other nodal assessment strategies. OBJECTIVE We conducted a systematic review to evaluate the diagnostic accuracy and clinical impact of sentinel lymph node mapping in the management of endometrial cancer. DATA SOURCES We searched Medline, Embase, and the Coch...