Abstract Although necrosis is common in brain metastasis (BM), its biological and clinical significances remain unknown. We evaluated extent differences by primary cancer subtype correlated BM to overall survival post craniotomy. analyzed 145 patients receiving Necrosis tumor ratio (NTR) was measured. Patients were divided into two groups NTR: BMs with sparse abundant necrosis. Clinical feature...

Piguet, P.F., Grau, G.E. & Vassalli, P. (1990). Subcutaneous perfusion of tumor necrosis factor induces local proliferation of fibroblasts, capillaries, and epidermal cells, or massive tissue necrosis. Am. J. fathot., 136, 103-I 10. Piguet, P.F., Grau, G.E., Allet, B. & Vassalli, P. (1987), Tumor necrosis factor is an effector of skin and gut lesions of the acute phase of graft-versus-host dise...

AIM To examine the usefulness of the histopathological finding of tumor necrosis for stratifying TNM stage IV colorectal cancer in R0 status. PATIENTS AND METHODS We enrolled 98 patients with stage IV colorectal cancer, without residual disease after resection. The extent of necrosis was assessed using published thresholds, the extent was graded as "absent", "moderate" (<30% of tumor area), o...

Bimekizumab is a monoclonal IgG1 antibody that selectively inhibits interleukin-17A and interleukin-17F. The efficacy safety of bimekizumab as compared with the tumor necrosis factor inhibitor adalimumab in patients moderate-to-severe plaque psoriasis have not been extensively examined.

aim : to create an orthotopic hepatoma model with local metastasis monitored with ultrasound could be created as a platform for testing new treatments.   background : hepatoma accounts for 25% of liver tumors in children with poor overall survival. intraabdominal metastasis are present in 35% of patients at time of diagnosis.  we hypothesized that an orthotopic tumor model with local metastasis...

Background: Inflammatory response following surgical trauma has long been a matter of study. Results, however, have been varied. We sought to assess changes in the levels of proinflammatory and anti-inflammatory cytokines in patients undergoing laparoscopic and open cholecystectomy and their impact on the clinical outcome of patients concerning the postoperative pain score.Methods: The study in...

Patients with pT1aN0M0 renal cell carcinoma (RCC) generally have good prognosis, and recurrence is rare. However, metastasis develops postoperatively in a small number of patients with pT1aN0M0 RCC. The present study was undertaken to identify predictors for recurrence in patients with pT1aN0M0 RCC. We reviewed the clinicopathological factors of 133 patients with pT1aN0M0 RCC who underwent radi...