Research into tumorigenic pathways can aid in the development of more efficient cancer therapies and provide insight physiological regulatory mechanisms employed by rapidly proliferating cells. Due to severe side effects chemotherapeutic medications, plant chemicals their analogues are now explored frequently for treatment prevention colorectal (CRC), opening stage new phytotherapeutic strategi...

Abstract Acute Myeloid Leukemia (AML) is the abnormal differentiation of hematopoietic stem cells in bone marrow into malignant blasts. The leukemic environment plays an important role during disease progression, by shaping immune landscape interacting with these Mounting evidence suggests neutrophils are complicit within tumors enhancing tumorigenesis and immunosuppression; however, little kno...

One novel p-terphenyl compound, polyozellic acid (1), and its acetone adduct (3), along with a known p-terphenyl compound, thelephoric acid (2), were isolated from the mushroom Polyozellus multiplex. Their molecular structures were determined by spectroscopic analysis, X-ray crystallographic analysis, and chemical modification. In some assays related to angiogenesis, compounds 1 and 2 in partic...

Paclitaxel (Taxol) and docetaxel (Taxotere) have been shown to inhibit angiogenesis at low concentrations that do not affect cancer cell proliferation. Here, we used rat aortic rings and human umbilical vein endothelial cells to evaluate the influence of their formulation vehicles Cremophor EL and polysorbate 80, as well as serum binding proteins on taxane-mediated antiangiogenesis. The data sh...