Macroautophagy is a conserved degradative pathway in which a double-membrane compartment sequesters cytoplasmic cargo and delivers the contents to lysosomes for degradation. Efficient formation and maturation of autophagic vesicles, so-called phagophores that are precursors to autophagosomes, and their subsequent trafficking to lysosomes relies on the activity of small RAB GTPases, which are es...

This paper deals with the numerical solution of the time–dependent Schrödinger– Poisson system in the spherically symmetric case. Since the problem is posed on an unbounded domain one has to introduce artificial boundary conditions to confine the computational domain. The main topic of this work is the construction of a so–called discrete transparent boundary condition (TBC) for a Crank–Nicolso...

BACKGROUND Hospitals are faced with increasingly resistant strains of micro-organisms. When it comes to disinfection, individual parts of electronic equipment of angiology diagnostics such as patient couches of computer tomography (CT) and magnetic resonance imaging (MRI) scanners prove to be very hard to disinfect. Disinfectants of choice are therefore expected to possess properties such as ra...

Abstract Thermal boundary resistance (TBR) between a single-walled carbon nanotube (SWNT) and matrices of solid and liquid argon was investigated by performing classical molecular dynamics simulations. Thermal boundary conductance (TBC), i.e. inverse of TBR, was quantified for a range of nanotube lengths by applying a pico-second heat pulse to the SWNT and observing the relaxation. The SWNT-len...

OBJECTIVE The study aimed to investigate optimal surgical timing, methods, and clinical efficacy of bifrontal decompression craniotomy (BDC) on traumatic bifrontal contusions (TBC). METHODS A retrospective analysis was performed of 98 patients with TBC who underwent BDC of 2510 patients with traumatic brain injury. The operation-timing score was used to determine surgical timing. RESULTS Ni...

Upconversion luminescence imaging of thermal barrier coatings (TBCs) has been shown to successfully monitor TBC delamination progression during interrupted furnace cycling. However, furnace cycling does not adequately model engine conditions where TBC-coated components are subjected to significant heat fluxes that produce through-thickness temperature gradients that may alter both the rate and ...

Cryptococcus neoformans was isolated from nine pathological specimens cultured for mycobacteria. Five of these were recovered only in liquid TBC medium in the absence of growth on conventional substrates.

Modern gas turbine hot sections need to be protected from elevated temperature and damaging environments. This protection starts as a typically two layer coating system, the base layer or bond coat (BC) acts as a corrosion barrier and a kind of buffer for the thermal mismatch between the base material and the second top thermally protective layer or Thermal Barrier Coating (TBC). The BC is norm...

Autophagy is an evolutionarily conserved process that enables catabolic and degradative pathways. These pathways commonly depend on vesicular transport controlled by Rabs, small GTPases inactivated by TBC/RabGAPs. The Rac1 effector TBC/RabGAP Armus (TBC1D2A) is known to inhibit Rab7, a key regulator of lysosomal function. However, the precise coordination of signaling and intracellular traffick...