PURPOSE Antiproliferative and antiosteoclastic activity from preclinical models show potential for dasatinib, an oral SRC and SRC family kinase inhibitor, as a targeted therapy for patients with prostate cancer. This phase II study investigated the activity of dasatinib in patients with metastatic castration-resistant prostate cancer (CRPC). EXPERIMENTAL DESIGN Chemotherapy-naive men with CRP...

OBJECTIVE To analyze the accuracy of hemoglobin (Hb) concentrations as a diagnostic indicator of iron deficiency in pregnant women and to measure the efficacy of oral iron therapy using Hb z-scores rather than Hb absolute values. METHODS The sensitivity and specificity of Hb < 11.0 g/dL, and its receiver operating characteristic (ROC) curve, in the diagnosis of iron deficiency (serum ferritin...

Accepted for publication 10 November 1994 Abstract Omeprazole plus amoxicillin cures Helicobacter pyloni infection. The hypothesis was tested that low acidity is a predictor of outcome. Fifty patients with relapsing or complicated, or both Hpylori positive duodenal (n=25) or gastric ulcer (n=25) were randomly treated with either omeprazole 20 mg twice daily plus amoxicillin 1 g twice daily or w...

The purpose of the present study is to investigate the effect of cognitive errors avoidance teaching through narrative therapy on depression and dysfunctional attitude of elementary girl students. This project was an experimental study with pretest-posttest-follow up (1 month) design. To measure depression and dysfunctional attitude, Depression Self-Rating Scale (DSRS) was used and to evalu...

IMPORTANCE Hyperkalemia is a potentially life-threatening condition predominantly seen in patients treated with renin-angiotensin-aldosterone system (RAAS) inhibitors with stage 3 or greater chronic kidney disease (CKD) who may also have diabetes, heart failure, or both. OBJECTIVES To select starting doses for a phase 3 study and to evaluate the long-term safety and efficacy of a potassium-bi...

BACKGROUND/AIMS To evaluate the efficacy of brimonidine purite versus dorzolamide given twice daily in primary open angle glaucoma or ocular hypertensive subjects. METHODS In this double masked, multicentre, prospective, crossover comparison 33 subjects were randomised to brimonidine purite or dorzolamide for the first 4 week treatment period after a 4 week washout. Subjects began the opposit...

Selenium is an essential trace element and has been shown to protect the rats against dietary liver necrosis. This study was designed to evaluate the effects of selenium supplementation on different biochemical parameters in thioacetamide induced cirrhotic rats. For this purpose 24 male Albino wistar rats were divided into four groups (n=6). Group I, remained healthy control rats, Group II, rec...

AIMS To investigate the effect on the hypothalamo-pituitary-adrenal (HPA) axis of treatment with budesonide, 400 microg once daily, morning or evening, or 200 microg twice daily, and 800 microg twice daily via Turbuhaler in a randomized, placebo-controlled, double-blind, double-dummy crossover study. METHODS Healthy men received budesonide, 400 microg in the morning (08.00-09.00 h) or evening...

dopaminergic signaling is one of the regulatory pathways being investigated for its implication in glucose metabolism. the aim of this study was to determine the effect of cabergoline on biochemical and anthropometric parameters in prediabetes stage (impaired fasting glucose and impaired glucose tolerance). in this double blind, placebo-controlled, pilot study, 27 prediabetic adults were random...

the optimal fractionation schedule for radiotherapy of head and neck cancer has been controversial. the objective of this randomized trial was to test the efficacy of hyperfractionation vs. standard fractionation. patients with squamous cell carcinoma of head and neck organs were randomly assigned to receive radiotherapy delivered with a) standard fractionation at 2 gy/fraction/day, 5 days/week...