Uniformly sized microparticles of poly(D,L-lactic-co-glycolic) (PLGA) acid, with controllable median diameters within the size range 40-140 microm, were successfully prepared by membrane emulsification of an oil phase injected into an aqueous phase, followed by solvent removal. Initially, simple particles were produced as an oil in water emulsion, where dichloromethane (DCM) and PLGA were the o...

BACKGROUND Drug design against human immunodeficiency virus type 1 (HIV-1) integrase through its mechanistic study is of great interest in the area in biological research. The main obstacle in this area is the absence of the full-length crystal structure for HIV-1 integrase to be used as a model. A complete structure, similar to HIV-1 of a prototype foamy virus integrase in complex with DNA, in...

Recent discoveries indicate that the foamy virus (FV) (Spumavirus) ancestor may have been among the first retroviruses to appear during the evolution of vertebrates, demonstrated by foamy endogenous retroviruses present within deeply divergent hosts including mammals, coelacanth, and ray-finned fish. If they indeed existed in ancient marine environments hundreds of millions of years ago, signif...

The formation of foamy macrophages by sequestering extracellular modified lipids is a key event in atherosclerosis. However, there is controversy about the effects of lipid loading on macrophage phenotype, with in vitro evidence suggesting either pro- or anti-inflammatory consequences. To investigate this in vivo we compared the transcriptomes of foamy and non-foamy macrophages that accumulate ...

Within the field of retrovirus, our knowledge of foamy viruses (FV) is still limited. Their unique replication strategy and mechanism of viral persistency needs further research to gain understanding of the virus-host interactions, especially in the light of the recent findings suggesting their ancient origin and long co-evolution with their nonhuman hosts. Unquestionably, the most studied memb...

The ternary phase diagram for N-[3-lauryloxy-2-hydroxypropyl]-L-arginine L-glutamate (C12HEA-Glu), a new amino acid-type surfactant, /oleic acid (OA)/water system was established. The liquid crystal and gel complex formations between C12HEA-Glu and OA were applied to a preparation of water-in-oil (W/O) emulsions. Stable W/O emulsions containing liquid paraffin (LP) as the oil and a mixture of C...

Here we shall introduce the concept of harmonic balls in subdomains of Rn, through a mean value property for a sub-class of harmonic functions on such domains. In the complex plane, and for analytic functions, a similar concept fails to exist due to the fact that analytic functions can not have prescribed data on the boundary. Nevertheless, a two-phase version of the problem does exists, and gi...

The field distribution, dielectric constant, and loss in a two-phase composite, in which phase A is distributed inside a square matrix of phase B, have been calculated using the finite-element method ~FEM!. The calculation was carried out by taking into account different shapes for phase A, such as circles, triangles, and rings with different sizes. The modeling by FEM in the dielectric composi...

in this paper, the problem of turbulent forced convection flow of water- alumina nanofluid in a uniformly heated pipe has been thoroughly investigated. in numerical study, single and two-phase models have been used. in single-phase modeling of nanofluid, thermal and flow properties of nanofluid have been considered to be dependent on temperature and volume fraction. effects of volume fraction a...

The spatial averaging theorem is applied to rigorously derive continuum-scale equations of radiative transfer in two-phase media consisting of either two semi-transparent or one semitransparent and one opaque homogeneous phases in the limit of geometric optics. The derivations are based on the equations of radiative transfer and the corresponding boundary conditions applied at the discrete-scal...