Volume 84, Number 9 www.aafp.org/afp American Family Physician 1035 A 51-year-old man developed a mild fever and several serous vesicles on an erythematous base on his trunk (Figures 1 and 2) three months after having a renal transplant. During the following 10 days, similar lesions developed on his neck, upper arms, lower back, and inner thigh. The patient had the transplant because of end-sta...

During a screening program, a 24-year-old woman presented an itchy nodule above the upper lip, 5 × 5 mm in size with irregular pigmentation, which had enlarged over the previous three weeks. Personal clinical history revealed a recurrent Herpes virus infection. Dermoscopy showed light brown irregular pigmentation, milia-like cysts and an atypical vascular pattern. Reflectance confocal microscop...

INTRODUCTION The Centers for Disease Control and Prevention has recommended using a nucleic acid amplification test (NAAT) for diagnosing pulmonary tuberculosis (TB) but there is a lack of data on NAAT cost-effectiveness. METHODS We conducted a prospective cohort study that included all patients with an AFB smear-positive respiratory specimen at Grady Memorial Hospital in Atlanta, GA, USA bet...

BACKGROUND The World Health Organization estimated in 2010 that 8.8 million new tuberculosis (TB) cases. About one-third of the world's population is infected and 10% will develop active TB disease. While cultures remain the international gold standard for diagnosing TB disease, in many other low-income countries, sputum smears remain the only and most accessible tool with which to diagnose act...

OBJECTIVE To evaluate the validity of the fixed mathematical relationship between the annual risk of tuberculous infection (ARTI), the prevalence of smear-positive tuberculosis (TB) and the incidence of smear-positive TB specified as the Styblo rule, which TB control programmes use to estimate the incidence of TB disease at a population level and the case detection rate. METHODS Population-ba...