AIMS Although a 140 U/kg dose of unfractionated heparin (UFH) was comparable with bivalirudin in terms of net clinical outcome in the Intracoronary Stenting and Antithrombotic Regimen: Rapid Early Action for Coronary Treatment (ISAR-REACT) 3 trial, it was associated with a higher risk of bleeding. We designed this study to assess whether a reduction in the UFH dose from 140 to 100 U/kg is assoc...

Abstract Background A subcutaneous (SC) formulation of IFX has recently been shown to be as effective intravenous (IV) in a randomised trial but there are no real world data support elective switching. We aimed assess the effectiveness an switching program from IV SC patients with IBD. Methods Patients on maintenance were included this retrospective multi-centre cohort study across two sites. D...

The chemical and mechanical properties of extracellular matrices (ECMs) modulate diverse aspects of cellular fates; however, how regional heterogeneity in ECM composition regulates developmental programs is not well understood. We discovered that fibronectin 1 (Fn1) is expressed in strikingly non-uniform patterns during mouse development, suggesting that regionalized synthesis of the ECM plays ...

ZnO nanoparticles (NPs) are engineered nanoparticles used in many commercial products inclusive of cosmetics, paints, textiles, and sanitary products. ZnO NPs are potent in protecting the skin against UV radiation so, they are used as ingredients in sunscreen and moisturizing creams/lotions and hence the study of their toxicity is essential. On the one hand, nanoparticles, due to their small si...

AIM To determine the safety and effectiveness of biphasic insulin aspart 30 (BIAsp 30) in Algerian patients with type 2 diabetes initiating insulin or switching from prior insulin therapy. METHODS Insulin-naive and insulin-experienced patients, including prior basal insulin users, starting BIAsp 30 were evaluated in this sub-analysis of the 24-week, open-label, non-interventional A₁chieve stu...

BACKGROUND Milrinone used for acute cardiac insufficiency could be of interest during cardiopulmonary resuscitation because of its positive inotropic effects. In this study, the combination of milrinone-vasopressin was compared with epinephrine and vasopressin, as well as with the combination of epinephrine-vasopressin, in reference to hemodynamics. METHODS Thirty-two pigs underwent ligation ...

FFR-rFVIIa is an inactivated recombinant factor VIIa (rFVIIa) that inhibits the binding of factor VIIa to tissue factor (TF). It has been shown to prevent TF-induced thrombosis in animals. The present study is a substudy of the Active Site Inhibited Seven (ASIS) trial and examines the antithrombotic effect of 3 doses of FFR-rFVIIa in 24 patients undergoing percutaneous coronary intervention (PC...

Gaucher disease type 1 is caused by the defective activity of the lysosomal enzyme, acid beta-glucosidase (GCase). Regular infusions of purified recombinant GCase are the standard of care for reversing hematologic, hepatic, splenic, and bony manifestations. Here, similar in vitro enzymatic properties, and in vivo pharmacokinetics and pharmacodynamics (PK/PD) and therapeutic efficacy of GCase we...

A study was conducted to determine the prevalence of intestinal parasites in children from eight schools located in Phuttamonthon District, Nakhon Prathom Province during November 2004 to December 2004. Stool samples were collected from 1920 students; age range from 7 to 12 years old, and examined for intestinal parasites by using formalin-ethyl acetate concentration technique. Of these subject...

As a former district nurse and latterly a tissue viability clinical nurse specialist (CNS), I have always been interested in patients with unmet psychosocial needs relating to chronic venous leg ulceration (Brown, 2003). The high recurrence rates of venous leg ulcers is well documented (Mayberry et al, 1991; Moffatt and Franks, 1995). It therefore always seemed a futile exercise to heal leg ulc...