نتایج جستجو برای: ucb
تعداد نتایج: 2313 فیلتر نتایج به سال:
Background: Umbilical cord blood hematopoietic stem cells (UCB-HSCs) are an attractive source for transplantation. The generation of megakaryocyte-committed cells could lead to shorten period of thrombocytopenia after HSCs transplantation. Platelet lysate (PL) unlike fetal bovine serum (FBS) can prevent immune problems as well as avert transmission of certain diseases to the recipient. In this ...
In this paper, we construct the uniform confidence band (UCB) of a time-varying trend in a partially linear model. A two-stage local linear regression is proposed to estimate the time-varying trend. Based on this estimate, we develop an invariance principle to construct the UCB of the trend function. The proposed methodology is used to estimate the Non-Accelerating Inflation Rate of Unemploymen...
Background: Bone Marrow Transplantations (BMT) are limited by low CD34+ cell counts in umbilical cord blood (UCB) and these cells need to be expanded for success in such procedures. To achieve this goal, ex vivo expansion of hematopoietic stem cells (HSCs) by enhancing their self-renewal activity on demineralized bone matrix (DBM) scaffold coated with mesenchymal progenitor cells (MPCs) and unr...
Although the infusion of umbilical cord blood (UCB) from multiple donors can be a strategy to overcome the cell dose limitation frequently encountered in UCB transplantation, clinical trials have revealed that cells from one donor dominate engraftment. To investigate the origin of and the factors influencing this inequality, we performed mixed transplantation of 2 UCB units with varying degrees...
Transplantation-related mortality (TRM) is high after HLA-mismatched umbilical cord blood (UCB) transplantation (UCBT). In utero, exposure to noninherited maternal antigen (NIMA) is recognized by the fetus, which induces T regulator cells to that haplotype. It is plausible that UCBTs in which recipients are matched to donor NIMAs may alleviate some of the excess mortality associated with this t...
Allogeneic stem cell transplantation has become a curative treatment option for many patients with haematological malignancies, bone marrow failure syndromes, thalassaemia, sickle-cell disease and some rare disorders of the blood and bone marrow. Ideally, stem cells from the peripheral blood or bone marrow are sourced from sibling donors or from a matched unrelated donor if a sibling donor is n...
Brandon A. Jones(1), Alireza Doostan(2), and George Born(3) (1)(3)Colorado Center for Astrodynamics Research, University of Colorado Boulder, UCB 431, Boulder, Colorado, 80309, 303-735-4490, [email protected], [email protected] (2)Department of Aerospace Engineering Sciences, University of Colorado Boulder, UCB 429, Boulder, Colorado, 80309, 303-492-7572, alireza.doostan@colorad...
The UCT algorithm, which combines the UCB algorithm and Monte-Carlo Tree Search (MCTS), is currently the most widely used variant of MCTS. Recently, a number of investigations into applying other bandit algorithms to MCTS have produced interesting results. In this research, we will investigate the possibility of combining the improved UCB algorithm, proposed by Auer et al. [2], with MCTS. Howev...
We consider a learner’s problem of acquiring data dynamically for training a regression model, where the training data are collected from strategic data sources. A fundamental challenge is to incentivize data holders to exert effort to improve the quality of their reported data, despite that the quality is not directly verifiable by the learner. In this work, we study a dynamic data acquisition...
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