Abstract Introduction Although initially believed to be less severe than heart failure with reduced ejection fraction (HFrEF), preserved (HFpEF) prevalence has increased and accounts for as much 50% of cases [1,2]. Treatment options remain limited aim primarily symptom relief improvement quality life [2]. Urocortin-2 (Ucn-2) belongs the corticotrophin-releasing hormone (CRH) family been found h...

— The possibility of creating a UCN source at periodic pulsed reactor is considered. It shown that the implementation principle time focusing based on nonstationary neutron diffraction and idea pulse filling trap allow one to create sufficiently intense reactor.

CRH/urocortin-receptor-binding protein (CRH/UCN-R-BP) mRNAs are dynamically expressed in the primate ovary during the menstrual cycle. Therefore, studies were designed to localize CRH/UCN-R-BP mRNAs to ovarian cell types, quantitate protein expression during the corpus luteum (CL) lifespan, and investigate the role of this system in the macaque ovary at midcycle. Monkey ovaries were removed dur...

Peptides encoded by the urocortin II (Ucn II) gene were recently identified as new members of the corticotropin-releasing factor (CRF) family. Ucn II is a specific ligand for the type 2 CRF receptor. Using RT-PCR, DNA sequencing, and immunofluorescence staining, we report the expression of Ucn II mRNA in several human and mouse (m) neuronal cell lines. Using these neuronal cell lines, we provid...

DNA damage induces cell cycle arrest to provide time for repair and enhance cell survival. The Chk1 inhibitor 7-hydroxystaurosporine (UCN-01) can overcome both S and G2 arrest and drive cells through a lethal mitosis. S-phase arrest induced by the topoisomerase I inhibitor SN38 results from activation of Chk1 and degradation of Cdc25A phosphatase that occurs independent of p53 status. However, ...

This article reviews the development of various sources for ultracold neutrons (UCNs) at Petersburg Nuclear Physics Institute (PNPI). For 45 years, PNPI has proposed and manufactured cryogenic devices neutron conversion to low energies. Based on beryllium, hydrogen deuterium, they can be operated in intense radiation fields near core a nuclear reactor. A more recently launched UCN source utiliz...

We have experimentally studied growing a large (about 1 liter) ortho-deuterium crystal in real UCN source cryostat and recorded the process optically using camera. The best quality was observed when directly from vapor phase. grown at different mass flows of deuterium annealed temperatures. Optimum conditions were found for both, obtaining an transparent cooling it down with minimal damage. tha...

Corticotropin-releasing hormone (CRH) is a key regulator of the mammalian stress response, mediating a wide variety of stress-associated behaviors including stress-induced inhibition of reproductive function. To investigate the potential direct action of CRH on pituitary gonadotrope function, we examined CRH receptor expression and second messenger signaling in alpha T3-1 cells, a murine gonado...

PURPOSE Antineoplastic agents often achieve antitumor activity at the expense of close to unacceptable toxicity. One potential avenue to improve therapeutic index might combine agents targeting distinct components of the same growth regulatory pathway. This might lead to more complete modulation of the target pathway at concentrations lower than those associated with limiting adventitious toxic...

The incoherent approximation (IA) is often used for calculating the one-phonon inelastic neutron scattering cross section arbitrary solids. It valid thermal neutrons but slow it requires a correction, which significant isotopes that are strong coherent scatterers. In this article, we present extension of Placzek--Van Hove corrections in limit low temperatures using example solid \emph{ortho}-de...