Corticotropin releasing hormone (CRH) is a key hormone in integrated response to stress, acting as the major regulator of the hypothalamic-pituitary-adrenal axis. Recently, local production of CRH has been detected in normal human colonic enterochromaffin cells. CRH is locally secreted in granulomatous and arthritic tissues in rats and humans, where it seems to act as a local proinflammatory ag...

New onset ulcerative colitis appearing with or soon after an associated comorbidity represents a unique opportunity to analyze and identify the events that may have triggered the colonic inflammation. The characteristic colonic mucosal inflammatory manifestations observed in ulcerative colitis lends itself to a common pathway analysis within the pathophysiology of associated comorbid triggering...

Primary colonic lymphoma is an increasingly recognised complication of ulcerative colitis. We report the first known case of rectal lymphoma occurring after colectomy and ileorectal anastomosis in ulcerative colitis.

BACKGROUND Decreased synthesis of the predominant secretory human colonic mucin (MUC2) occurs during active ulcerative colitis. AIMS To study possible alterations in mucin sulphation and mucin secretion, which could be the cause of decreased mucosal protection in ulcerative colitis. METHODS Colonic biopsy specimens from patients with active ulcerative colitis, ulcerative colitis in remissio...

References 1. Sandborn WJ, Feagan BG, Marano C, et al. Subcutaneous golimumab induces clinical response and remission in patients with moderate-to-severe ulcerative colitis. Gastroenterology 2014;146:85–95. 2. Sandborn WJ, Feagan BG, Marano C, et al. Subcutaneous golimumab maintains clinical response in patients with moderate-to-severe ulcerative colitis. Gastroenterology 2014;146:96–109. 3. Ru...

background there are great variations in the incidence and prevalence of inflammatory bowel diseases (ibd) among different populations. epidemiologic studies mainly come from north america and europe. studies from iran are mostly data on the adult population from the northern region of the country. methods medical records of 37 pediatric patients (≤ 18 years of age) admitted in the pediatric ga...

background : the incidence of inflammatory bowel disease (ibd) may have changed over time. the incidence and prevalence of ibd appears to be lower in asia and south america. although once believed to be infrequent in iran, there has been a rising trend in ibd over the past two decades. however, in iran there is no data about the incidence and prevalence of ibd. materials and methods : â demogra...

aim : the study aims to document the oral lesions in patients with uc. background : inflammatory bowel disease (ibd) is comprised of two chronic, tissue-destructive and clinical entities including crohn's disease (cd) and ulcerative colitis (uc), both of which are immunologically based. patients and methods : the population of the study includes fifty patients with uc, as the experimental group...