One of the most important applications of Doppler ultrasonography in obstetrics is the detection of fetal anemia in pregnancies complicated by either red-cell alloimmunization or by other causes of fetal anemia. Doppler of the umbilical artery also has prognostic value in pregnancies affected by twin-twin transfusion syndrome undergoing in-utero intervention. Another potential major application...

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The application and development of obstetric Doppler velocimetry provide a basis for the investigation of placental insufficiency and demonstrate the dynamic behavior of fetal circulation during hypoxia. In clinical practice, assessing hemodynamics in three vascular regions involved in pregnancy, namely the uterine, umbilical and middle cerebral arteries, has become routine. Roughly, the cerebr...

INTRODUCTION Although the human umbilical cord (UC) has been previously considered a medical waste, its use as a main source of fetal stem cells for regenerative medicine applications has increased over the past few years. The aim of the study was to assess the impact of the maternal age on the expression of mesenchymal stem cells (MSC) markers CD105 and CD29 in the different areas of human UC....

A female neonate born at term with a mass at the umbilicus (Fig. 1). Prenatal ultrasound at 22 weeks gestation had noted polyhydramnios, macrosomia, a single umbilical artery and a small ventricular septum defect. Fluorescence in situ hybridization (FISH) analysis at 27 weeks gestation did not identify any chromosomal abnormalities. At birth, the umbilical ring seemed intact and there was no re...

OBJECTIVE To examine the predictive value of clinical examination, laboratory tests and Doppler ultrasound examination in systemic lupus erythematosus (SLE) and/or antiphospholipid syndrome (APS) pregnancies. METHODS A prospective study of 116 pregnancies followed in a single tertiary referral centre. Outcomes analysed were fetal/neonatal death and adverse pregnancy outcome. Univariate analys...

Background: Twin anaemia-polycythaemia sequence (TAPS) is a form of chronic twin-to-twin transfusion syndrome (TTTS) secondary to slow unidirectional blood flow across minuscule arteriovenous (AV) anastomoses. We present case presumed TAPS unusual, large, proximal Case report: Monochorionic diamniotic (MCDA) twins were born at 25+6 weeks gestation following intrauterine fetal demise. Ultrasound...

After a single intramuscular dose of flunitrazepam 0.015 mg kg-1 (n = 14) in women 37 to 41 weeks pregnant, the concentrations in the umbilical artery and amniotic fluid were significantly lower than in maternal venous plasma. Although the difference between the maternal venous and umbilical venous plasma concentrations was not significant, the mean fetomaternal ratio was 0.7. The plasma protei...

Background Serotonin (5-HT), is a vasoactive substance involved in physiological functioning of fetoplacental blood flow and continuous modulation of smooth muscle tone in umbilical vein and arteries. Since umbilical blood vessels have been shown to be deficient in autonomic innervation, the action of local autocrine vasoactive substances (including serotonin) is of considerable importance. Alt...

Background: Doppler ultrasonography enables the investigation of vascular blood flow indexes in gestational assessment, being able to detect resistances that can affect fetal and maternal circulation, such as cases placental insufficiency, associated with cerebral oxygenation deficit distress. The study aims assume hemodynamically normal values final third gestation bitches, umbilical, uteropla...