The need for new classes of antibacterials is genuine in light the dearth clinical options treatment bacterial infections. prodigious discoveries antibiotics during 1940s to 1970s, a period wistfully referred as Golden Age Antibiotics, have not kept up face emergence resistant bacteria past few decades. There has been renewed interest old drugs, repurposing existing and pairing synergistic or a...

the production and application of pet tracers has been a unique step in the progress of nuclear medicine in last two decades. the most important pet tracers include f-18, c-11 and n-13 radioisotopes and many nuclear medicine centers throughout the globe are using them. however some new tracers are under their way to the mass administration, currently being in the clinical trials or preliminary ...

Unconventional T cells are gaining center stage as important effector and regulatory cells that orchestrate innate and adaptive immune responses. Human Vγ9/Vδ2 T cells are amongst the best understood unconventional T cells, as they are easily accessible in peripheral blood, can readily be expanded and manipulated in vitro, respond to microbial infections in vivo and can be exploited for novel t...

In the present follow-up article of a previous one [1] we illustrate the use of the Unconventional Statistical Mechanics described and discussed in the latter. This is done via the analysis, resorting to Renyi approach, of experimental results in the case of so-called " anomalous " luminescence in nanometric quantum wells in semiconductor heterostructures, and the so-called " anomalous " cyclic...

This paper discusses modularization as a mechanism for improving the flexibility and comprehensibility of a system while allowing the shortening of its development time. The effectiveness of a "modulariza tion is dependent upon the criteria used in dividing the system into modules. Two system design problems are presented, and for each, both a conventional and unconventional decomposition are d...

The proper expression and function of several unconventional myosins are necessary for inner-ear function. Mutations in MYO7A and MYO15 cause deafness in humans, and mice. Whereas mutations in Myo6 cause inner-ear abnormalities in mice, as yet no human deafness has been found to the result of mutations in MYO6. In the mammalian inner ear there are at least nine different unconventional myosin i...

The most prevalent disease-causing mutation of CFTR is the deletion of Phe508 (ΔF508), which leads to defects in conventional Golgi-mediated exocytosis and cell surface expression. We report that ΔF508-CFTR surface expression can be rescued in vitro and in vivo by directing it to an unconventional GRASP-dependent secretion pathway. An integrated molecular and physiological analysis indicates th...

Citation: Odom KJ, Omland KE, McCaffrey DR, Monroe MK, Christhilf JL, Roberts NS and Logue DM (2016) Typical Males and Unconventional Females: Songs and Singing Behaviors of a Tropical, Duetting Oriole in the Breeding and Non-Breeding Season. Front. Ecol. Evol. 4:14. doi: 10.3389/fevo.2016.00014 Typical Males and Unconventional Females: Songs and Singing Behaviors of a Tropical, Duetting Oriole...

Coexistence or competition of superconductivity and magnetic order remains an important issue in condensed matter physics. While conventional superconductivity is generally incompatible with magnetism, the magnetic 4f or 5f moments in heavy-fermion superconductors play a crucial role for the appearance of unconventional superconductivity. Similar to the high-temperature cuprate superconductors,...

DFT calculations have demonstrated that the unconventional bifunctional Brønsted-Lewis acid activation mode is generally applicable to a range of nucleophilic conjugate additions catalyzed by bicyclic guanidine catalysts. It competes readily with the conventional bifunctional Brønsted acid mode of activation. The optimal pro-nucleophiles for this unconventional bifunctional activation are acidi...