disposition and transportation of anticancer drugs by human serum albumin (hsa) affects their bioavailability, distribution and elimination. in this study, the interaction of a set of anticancer drugs with hsa was investigated by molecular dynamics and molecular docking simulations. the drugs' activities were analyzed according to their docking scores, binding sites and structural descriptors. ...

A new fluid property module, EOSRn, was developed for TOUGH2 to simulate the transport of the radon gas (Rn) in saturatedunsaturated soils. It is an enhanced version of the EOS7R module for radionuclide transport, with a source term added in the transport equation to model radon generation by emanation from radioactive decay of the soil radium (Ra) content. We implemented physical properties of...

It has been popularly assumed, at least since the time of Pliny the Elder [1], that the hearing of moles and other subterranean mammals is acute, perhaps to compensate for their poor vision. In recent times, behavioural audiograms of subterranean species (most studies have been of rodents) have shown that audition is biased towards unusually low frequencies for such small mammals, typically bei...

To establish an alternative analytical framework for the elastic-wave imaging of underground cavities, the focus of this study is an extension of the concept of topological derivative, rooted in elastostatics and shape optimization, to three-dimensional elastodynamics involving semiinfinite and infinite solids. The main result of the proposed boundary integral approach is a formula for topologi...

Microbiological activity is a general term which includes all metabolic reactions and interactions of the soil microflora and macrofauna.1 Soil microorganisms contribute to soil fertility and aggregate formation in degraded soils.2 However, it is only during the last decades that ecologists have beginning to explore the underground communities and their functional significance for the plant com...

Incipient faults usually emerge from partial discharges which eventually cause insulation degradation between two insulated cable cores. Early detection of incipient faults is of particular importance because insulation defects caused by incipient faults may lead to permanent faults in underground distribution networks. This paper presents a novel approach using S-transform and support vector r...

While ecosystem engineering is a widespread structural force of ecological communities, the mechanisms underlying the inter-specific associations between ecosystem engineers and resource users are poorly understood. A proper knowledge of these mechanisms is, however, essential to understand how communities are structured. Previous studies suggest that increasing the quantity of resources provid...

objectives: this study aimed to evaluate the effect of chlorhexidine (chx) application protocol on durability of marginal seal of class v composite restorations. materials and methods: class v cavities (4×2×1.5mm) were prepared in the buccal surfaces of 160 human third molars. the teeth were randomly divided into five groups (n=32) of (g1) chx+rinse+etching, (g2) chx+etching, (g3) etching+chx+r...

background: volume fraction (vf) and location of internal voids and gaps in relation to material type and cavity dimensions in ultraconservative restorations were investigated in this study. materials and methods: forty-eight round cavities of 1.3 mm mean diameter and 2.6 mm mean depth were made on buccal and lingual surfaces of recently extracted human teeth. these were fi lled and thermocycle...

This research project attempts to understand the complex information interactions between musicians, promoters, and audience members who perform/promote/transform residential basements into underground music venues. The goals of this project are (1) to obtain an understanding of the informationseeking practices that enable social actors to participate in an underground music scene, (2) to ident...