Under inpatient controlled conditions 4 patients with gout and hypertension were treated with varying doses of tienilic acid, a new uricosuric diuretic. Plasma urate levels were reduced by an average of 50% in association with significantly increased urinary urate excretion. A twice-daily regimen was considerably more effective than a single morning dosage in reduction of plasma urate, though b...

The fact that deposits of urates are found in the collecting tubules of the kidneys of about one-half of all infants dying during the first two weeks of life, indicates that, in all probability, similar deposits occur frequently in normal infants. Consequently, it must be assumed that such deposits are not often a source of any harm, which assumption accounts for the relatively slight considera...

Gout is the most common form of inflammatory arthritis and its incidence in the UK has steadily increased from 1.5% in 1997 to 2.5% in 2012.1,2 It is characterised by deposition of monosodium urate crystals in joints and tissues and usually presents with intermittent painful attacks followed by long periods of remission.3 It has been suggested that the management of gout in the UK remains subop...

High levels of uric acid cause accumulation of monosodium urate crystals. This formation of masses is called tophus. Intraosseous tophus deposits are rare, even for patients with gout. We report an unusual case of intraosseous tophus deposits in the os trigonum. The patient presented with ankle pain with no previous history of gout. On examination, tenderness on the posterior aspect of his ankl...

Serum Vitamin A, total protein, serum electrophoresis, were determined in pediatric patients with urolithiasis (mostly bladder stones) and compared to that of normal healthy volunteers. The level of Vitamin A in healthy volunteers was found to be significantly (P<0.001) higher than that of patients with urolithiasis. The amount of total serum protein, how­ever, was not significantly different i...

Ammonium acid urate urolithiasis is a quite rare condition. Our literature review of ammonium acid urate urolithiasis suggests that ammonium acid urate urolithiasis should be regarded as a general medical complication related to anorexia nervosa, and purging by laxative abuse might be a crucially important risk.

Investigation of the genetic basis of hyperuricaemia is a subject of intense interest. However, clinical studies commonly include hyperuricaemic patients without distinguishing between 'over-producers' or 'under-excretors' of urate. The statistical power of studies of genetic polymorphisms of genes encoding renal urate transporters is diluted if 'over-producers' of uric acid are included. We pr...

ments suggest that at physiological concentrations, only urate contributes to the artifactually high pre-dialysis values. When a standard serum sample was increased in concentration (in vitro) from 11.6 to 54 mmol/L in urea, from 97 to 1130 mmol/L in creatinine, and from 0.31 to 1.38 mmol/L in urate, values for apparent SFA were unaffected by urea or creatinine changes, but rose 13% in the pres...