BACKGROUND AND OBJECTIVES Peritoneal interstitial fibrosis and hyalinizing vasculopathy were induced by peritoneal dialysis and other associated conditions (e.g., uremia). A quantitative method for peritoneal biopsy evaluation is required to investigate possible causative factors and severity of the peritoneal dialysis-related peritoneal alterations. DESIGN, SETTING, PARTICIPANTS, & MEASUREME...

BACKGROUND Cerebrovascular accident is an important cause of death in patients with chronic renal failure. METHODS This study evaluated the interference of low-dose urokinase in peritoneal dialysis solution on uremic serum superoxide dismutase (SOD), malondialdehyde (MDA), nitric oxide (NO) and endothelin (ET) dynamics in patients with a cerebral infarction complicated by uremia. RESULTS Bo...

Chronic kidney disease (CKD) refers to the myriad problems that follow loss of kidney function. It results from a large number of diseases that either are systemic and damage the kidney or are intrinsic to the kidney ( Table 131-1 ). CKD has two characteristics. First, there is chronicity because the kidney damage of CKD is rarely repaired and loss of function persists, unlike the course of acu...

Conjugated estrogens shorten the prolonged bleeding time in uremic patients and are similarly effective in a rat model of uremia. We have previously demonstrated that the shortening effect of a conjugated estrogen mixture or 17beta-estradiol on bleeding time was abolished by the nitric oxide (NO) precursor L-arginine, suggesting that the effect of these drugs on hemostasis in uremia might be me...

Cardiac complications are the leading cause of mortality in patients with chronic renal failure. Secondary carnitine deficiency, which is frequently observed in hemodialysis patients, has been associated with cardiac hypertrophy and heart failure and may impair myocardial fatty acid oxidation. In chronic kidney disease, impaired carnitine homeostasis also may affect myocardial metabolism. In th...