Autonomic dysfunction is involved in the onset of salt-sensitive hypertension as baroreflex sensitivity (BRS) blunted hypertension. However, salt exhibits sex disparity because hypertension, blood pressure (BP) usually higher males when compared with females. The mechanism(s) underlying this sexual dimorphism not clear. We, therefore, designed study to determine BRS weanling male Sprague – Dawl...

OBJECTIVE The present study was designed to evaluate the effects of urban, traffic-related, fine particulate matter (PM2.5) on mice lung tumorigenesis under controlled exposure conditions. METHODS Four groups of female Swiss mice were treated with intraperitonial injections of urethane and saline solution. Urethane was used to start the carcinogenesis process. The animals were housed in two c...

tomas observed in these anhnals were larger than those elicited by the treatment with injected urethane only. The same amount of methylcholanthrene administered to rats in an analogous way produced tumors (sarcomas and squamous epltheliomas) in 30 per cent of the treated animals (3), while in the present series only 9 per cent of the rats had these tumors. The question, whether the production o...

Introduction: Pain as a complex process in central nervous system (CNS) has been studied by many researchers. Pain is controlled by several CNS pathways, one of the most important of which, is the descending noradrenergic system. This system begins from locus coeruleus (LC) nucleus in pons and ends in the spinal cord. In this research, the effect of pain induced by formalin was studied. Met...

Chronic inflammation is linked to carcinogenesis in several organ systems. In the lungs, NFB, a central effector of inflammatory responses, is frequently activated in non-small-cell lung cancer, but its role in tumor promotion has not been studied. Several lines of evidence indicate that ethyl carbamate (urethane)-induced lung tumor formation, a prototypical mouse model of multistage lung carci...

An increased number of tumor-associated macrophages (TAMs) that exhibit the M2 macrophage phenotype is related to poorer prognosis in cancer patients. MafB is a transcription factor regulating the differentiation of macrophages. However, involvement of MafB for the development of TAMs is unknown. This study was designed to investigate the role of MafB in a murine urethane-induced lung cancer mo...

Nrf2 activation promotes resistance to chemical carcinogenesis in animal models, but activating mutations in Nrf2 also confer malignant characters to human cells by activating antioxidative/ detoxifying enzymes andmetabolic reprogramming. In this study, we examined how these contradictory activities of Nrf2, cancer chemoprevention and cancer cell growth enhancement, can be reconciled in an esta...

KRAS, NRAS or HRAS genes are mutated to encode an active oncogenic protein in a quarter of human cancers. Redox-dependent reactions can also lead to Ras activation in a manner dependent upon the thiol residue of cysteine 118 (C118). Here, to investigate the effect of mutating this residue on tumorigenesis, we introduce a C118S mutation into the endogenous murine Kras allele and expose the resul...

The purpose of this study was to define the histopathological characteristics of pulmonary neoplastic lesions, especially focusing on the origin of tumor cells, in urethane-treated Tg rasH2 mice. Bronchiolar-alveolar adenomas/adenocarcinomas were observed in the lungs from all of the urethane-treated animals. Immunohistochemically, these tumors showed an alveolar epithelial type II (AE2) cell p...

conclusions the results of this study demonstrated that spinal anesthesia increased the chance of fertilization success. results there was no difference between the two groups regarding demographic variables. 15 of 100 patients (15%) in the general anesthesia group and 27 of 100 patients (27%) in the spinal anesthesia group had successful pregnancy after ivf; so, spinal anesthesia increased sig...