An elevated serum concentration of uric acid may be associated with an increased risk of acute kidney injury (AKI). The aim of this study was to investigate the impact of preoperative uric acid concentration on the risk of AKI after coronary artery bypass surgery (CABG). Perioperative data were evaluated from patients who underwent CABG. AKI was defined by the AKI Network criteria based on seru...

INTRODUCTION Uric acid is a cardiovascular risk marker associated with oxidative stress and inflammation. Recently, atrial fibrillation (AF) has been associated with inflammation and oxidative stress. We therefore investigated the association between AF and uric acid levels. METHODS Consecutive patients with AF and healthy control subjects were screened. Demographic, clinical, and echocardiog...

Uric acid has long been considered to be a metabolically inert endproduct of purine metabolism in the human (1, 2). This view has been challenged by Folin, Berglund, and Derick (3), who, in an extensive review of the subject, reported that only about 50 per cent of intravenously administered uric acid in man could be recovered. More recently, with the use of Nls-labeled uric acid, Benedict, For...

GLUT9 is a novel, facilitative glucose transporter isoform that exists as two alternative splice variants encoding two proteins that differ in their NH(2)-terminal sequence (GLUT9a and GLUT9b). Both forms of GLUT9 protein and mRNA are expressed in the epithelia of various tissues; however, the two splice variants are expressed differentially within polarized cells, with GLUT9a localized predomi...

recent studies show that, inflammation plays an important role in the initiation and progression of atherosclerosis and in the pathogenesis of acute cardiovascular events. there is a possible association between ventricular dysfunction following acute myocardial infarction and high sensitivity c-reactive protein (hs-crp) and uric acid. in this study we assessed the relationship between hs-crp a...

Several findings suggest lower levels of serum uric acid in multiple sclerosis (MS) patients. The aim of this study is to investigate relationships of uric acid serum levels in relapse-remitting (RR) MS patients with clinical activity of disease and blood-brain barrier (BBB) condition. Sixty-three definite RRMS patients and 40 controls divided into two groups: 20 healthy donors and 20 patients ...

It is presumed that uric acid is an end-product of human metabolism and, as such, is not further catabolized. This presumption is based largely upon indirect evidence such as the failure to demonstrate uricase in human tissues and the uncertain r81e of allantoin in human metabolism. On the other hand, Folin presented evidence that uric acid intravenously injected into humans could not be quanti...

BACKGROUND/AIM Psoriasis has been accepted as a systemic disease and it is known to be associated with various disorders including metabolic syndrome. High serum uric acid levels are also associated with the components of metabolic syndrome. In this study, we aimed to determine serum uric acid levels in patients with psoriasis and the association of uric acid levels with disease activity by tak...

Metabolic triggers are important inducers of the inflammatory processes in gout. Whereas the high serum urate levels observed in patients with gout predispose them to the formation of monosodium urate (MSU) crystals, soluble urate also primes for inflammatory signals in cells responding to gout-related stimuli, but also in other common metabolic diseases. In this study, we investigated the mech...

Current evidence suggests a direct association of uric acid with diabetes risk, but it is still unclear whether this is independent of risk factors such as obesity and diet. We aimed to investigate whether plasma uric acid concentrations are independently associated with incident type 2 diabetes and to investigate the role of a uric acid-related dietary pattern in this association. We used a ca...