The circadian rhythm of the urinary saturation of uric acid, sodium acid urate, and ammonium acid urate was studied in 5 normal healthy male volunteers before and during 5 days of treatment with sodium-potassium citrate (1 g t.i.d., 1 g q.i.d., or 3 g t.i.d.). Urinary saturation was estimated on the relative supersaturation scale of Marshall and Robertson. Uric acid relative supersaturation var...

PURPOSE Recent studies have suggested that renal phosphate leakage and the associated phosphaturia are significant underlying causes of calcium urolithiasis. The aims of this study were to assess whether phosphaturia relates to urinary metabolic abnormalities and recurrent stone formation. MATERIALS AND METHODS A database of patient histories and urine chemistries was analyzed for 1,068 conse...

PURPOSE We compared the effect of 3 animal protein sources on urinary stone risk. MATERIALS AND METHODS A total of 15 healthy subjects completed a 3-phase randomized, crossover metabolic study. During each 1-week phase subjects consumed a standard metabolic diet containing beef, chicken or fish. Serum chemistry and 24-hour urine samples collected at the end of each phase were compared using m...

The inhibitory effect of two kinds of Kampou medicine, Chorei-to and Gorei-san, on calcium oxalate crystallization in human urine, was examined. Chorei-to or Gorei-san was administered to 15 healthy male volunteers for three consecutive days under normal dietary conditions and 24-hour urine samples were collected before and after the administration. Urinary parameters including calcium, phospho...

This study was conducted to determine the effect of Tribulus terrestis extract on urinary risk factors in normal and 18 normal subjects were selected and administered once daily with 10 mL of T. terrestris extract for one week. Serum, urine collected between 10 pm and 6 am, and 24 h urine samples were analysed for urinary risk factors for stone formation on day 0 and day 8 after administration ...

Scurvy is associated with abnormal carbohydrate metabolism and diminished production of insulin (1). Banerjee et al. (2) observed increased accumulation of citrate, malate, and lactate in the tissues of scorbutic guinea pigs. This was possibly due to the insulin insufficiency associated with scurvy since prolonged injection of insulin to scorbutic guinea pigs diminished the tissue concentration...

Everted sacs of rat duodenum and ileum were used to study the effect of anions and organic ligands on the absorption of zinc. The uptake per unit weight of tissue was greater in duodenum than ileum, and it was influenced by the Zn concentration and pH of the incubation medium. The Zn uptake from inorganic salts in simple buffered medium varied in the order zinc sulphate greater than zinc chlori...