Urinary proteomics is emerging as a powerful non-invasive tool for diagnosis and monitoring of variety of human diseases. We tested whether signatures of urinary polypeptides can contribute to the existing biomarkers for coronary artery disease (CAD). We examined a total of 359 urine samples from 88 patients with severe CAD and 282 controls. Spot urine was analyzed using capillary electrophores...

Bioinformatics is a fast evolving field that combines biology, computer science, and statistics to analyze comprehend enormous volumes of biological data. As result the introduction high-throughput technologies like next-generation sequencing mass spectrometry, genomic proteomics research has generated data, necessitating development computational tools process extract useful insights from thes...

Proteomics, the large-scale study of all proteins an organism or system, is a powerful tool for studying biological systems. It can provide holistic view physiological and biochemical states given samples through identification quantification large numbers peptides proteins. In forensic science, proteomics be used as confirmatory orthogonal technique well-built genomic analyses. Proteomics high...

introduction the proteome is the full complement of proteins expressed by a cell or tissue at any given time or environmental condition. proteomics is the study and identification of this set or subset of proteins (abersold & man, 2003 cristea et al., 2004). whereas the genome is composed of all the potential genes that can be expressed as proteins, the proteome is composed of all proteins actu...

results at the end of the study, four 4 cases in the nelatone group and 12 cases in the foley group presented with uti (p = 0.01). no positive urine cultures were found in the control group. conclusions the nelatone catheters, compared with the foley ones, had a lower risk of uti in the long term use. verifying this claim by further studies can have an important role in reducing utis in patient...

Among omics, the proteomics assumes a unique role in that it offers the effectors or actuators of a biological condition. This brief review attempts to summarize the development in a relatively new but important subdiscipline of proteomics, the so-called nascent proteomics, and its potential applications in stroke research. First, we will discuss a few examples of proteomics-led discoveries in ...

The third International Conference of the Hellenic Proteomics Society, From Proteomics Research to Clinical Practice, took place in Nafplio (Greece), from 30 March to 1 April 2009. This year the conference was dedicated to the application of proteomics in clinical practice. Many scientists from different European counties participated in the conference, which made this event unique in the field...

egfr is a key molecule in cancer cells. egfr signaling was shown to promote tumor cell proliferation and survival, invasion and angiogenesis and mediate resistance to treatment, including ionizing radiation in preclinical models. we extracted proteins from astrocytoma (iii and iv) oligodendroglioma(iv) tumors and normal brain tissues and then evaluated the protein purity by bradford test and sp...

mitochondria play key roles in many cell functions including energy production, fatty acid metabolism, pyrimidine biosynthesis, calcium homeostasis, and aging. they also regulate crucial signaling cascades such as apoptosis and oxidative stress. the proteome is often used to investigate the functional correlations on protein levels. based upon the human, genome there is estimated 2000 to 2500 a...