Objective: To assess the usefulness of the routine urine culture in febrile young children. setting: Tertiary care teaching hospital design: One year’s prospective study from October 2009 to September 2010 Patients: 334 febrile young children who were less than 5 years of age, who were admitted to the paediatric ward. Results: Out of 334 febrile children, 27 cases were diagnosed to have UTI , w...

The antimicrobial activity of the intraurethrally administered probiotic Lactobacillus casei strain Shirota against Escherichia coli in a murine urinary tract infection (UTI) model was examined. UTI was induced by intraurethral administration of Escherichia coli strain HU-1 (a clinical isolate from a UTI patient, positive for type 1 and P fimbriae), at a dose of 1 x 10(6) to 2 x 10(6) CFU in 20...

The role of prophylactic antibiotics in children with ANH who are awaiting completion of postnatal investigations is controversial. Children with ANH have been shown to have a significantly higher risk of developing a urinary tract infection (UTI) than controls. While it is believed that prophylactic antibiotics will prevent urinary tract infections in children with VUR, it has yet to be proven...

Objective: To determine efficacy of fosfomycin in urinary tract infections occurring during pregnancy. Study Design: Descriptive study. Settings: Obstetrics & Gynecology Ward Dow University OJHA Campus, Karachi. Duration Study: 11-08-2021 till 12-02-2022 Subject and Methods: Total 147 pregnant women presented with were enrolled. Detailed demographics recorded after taking informed written c...

According to a 2019 systematic analysis, 1,270,000 deaths were attributed antimicrobial resistance (AMR), making it leading cause of death globally​[1]​. Urinary tract infection (UTI) has been identified as one the disease burdens associated with, and attributable to, AMR 53% all Gram-negative bacteraemia cases with known source are […]

AMPICILLIN was first introduced to the medical profession by Rolinson and Stevens in 1961. At the same time Brown and Acred detailed the pharmacology of the drug and some animal protection studies. Knudsen, Rolinson and Stevens (1961) in discussing the absorption and excretion, showed the drug was well absorbed orally and pointed out that 30% of the administered dose was excreted in the urine w...

BACKGROUND Stress urinary incontinence (SUI), the most common type of urinary incontinence (UI), is usually defined as leakage of urine during movement or activity which puts pressure on the bladder, such as coughing, sneezing, running or heavy lifting. It is reported in most countries that 15% to 40% of women struggle with SUI and its severe implications for daily life, including social intera...

Uropathogenic Escherichia coli (UPEC) strains suppress the acute inflammatory response in the urinary tract to ensure access to the intracellular uroepithelial niche that supports the propagation of infection. Our understanding of this initial cross talk between host and pathogen is incomplete. Here we report the identification of a previously uncharacterized periplasmic protein, YbcL, encoded ...

Chronic bacteriuria is a common occurrence among spinal-cord injury patients and others with neuropathic bladders. If bacteria are present in the urinary tract, the patient may develop symptoms of infection or remain asymptomatic. We have compared virulence properties of 28 Escherichia coli isolates from patients with symptomatic urinary tract infections (UTI) and 29 E. coli isolates from patie...