INTRODUCTION AND OBJECTIVES There are over 65,000 new cases of renal cell carcinoma (RCC) each year, yet there is no effective clinical screening test for RCC. A single report claimed no overlap between urine levels of aquaporin-1 (AQP1) in patients with and without RCC (Mayo Clin Proc. 85:413, 2010). Here, we used archived and fresh RCC patient urine to validate this report. METHODS Archived...

As it has been demonstrated previously that midkine (also known as neurite growth-promoting factor 2) protein levels in urine of bladder cancer (BCa) patients are increased compared to healthy controls, the present study validated the diagnostic utility of midkine in an independent patient cohort and compared the observed values with voided urine cytology (VUC), which is the current reference s...

Objective: Urinary tract infection (UTI) is common in children. Urine culture the gold standard method for diagnosing urine but it takes more than 48 h to give results. The objective evaluate diagnostic ability of modified nitrite test as a rapid screening diagnosis UTI Methods: An observational and cross-sectional study was conducted tertiary care hospital Udaipur over period 1 year. Children ...

OBJECTIVE Polyomavirus-associated nephropathy (PVAN) is a major cause of graft dysfunction after kidney transplantation. Therefore, routine screening for BK polyomavirus (BKV) infection with urine cytology or quantitative PCR-based assays has been recommended. Although less expensive than quantitative tests, qualitative PCR assays are not recommended for screening based on the assumption that t...

In Nigeria, schistosomiasis, caused predominantly by the species Schistosoma haematobium, is highly endemic in resource-poor communities. We performed a school-based survey in two rural communities in Osun State (Southwestern Nigeria) and assessed macrohaematuria, microhaematuria and proteinuria as indirect indicators for the presence of disease. Urine samples were inspected macroscopically for...

Urine testing has the advantage of being convenient, familiar to a range of healthcare professionals, and non-invasive. Urine testing for albumin has a well-established role in the management of the diabetic patient and the assessment of renal disease. Urinary measurement of N-terminal B type natriuretic peptide (NTproBNP) has been proposed as a potential tool for detection of cardiac failure. ...

OBJECTIVE To evaluate the performance of a rapid test for chlamydia with first void male urine samples as a potential tool for diagnosis and screening of chlamydial infection in men. DESIGN Evaluation of test performance in prospective cohort study. Settings A young people's sexual health centre (site 1) and a genitourinary medicine clinic (site 2) in the United Kingdom. PARTICIPANTS 1211 m...

OBJECTIVE To determine the validity of the Uriscreen, a rapid diagnostic test based on the detection of urine catalase for the early detection of urinary tract infection (UTI) in children, compared with standard urinalysis and dipstick tests. STUDY DESIGN. Cross-sectional study. STUDY POPULATION Children 1 month to 17 years of age who presented to the emergency department of a pediatric terti...