Gastroesophageal reflux is associated with adenocarcinoma in Barrett's esophagus, but the incidence of this tumor is rising, despite widespread use of acid-suppressing medications. This suggests that refluxed material other than acid might contribute to carcinogenesis. We looked for potentially carcinogenetic effects of two bile acids, deoxycholic acid (DCA) and ursodeoxycholic acid (UDCA), on ...

Objective We evaluated the effects of ursodeoxycholic acid (UDCA) on glucagon-like peptide-1 (GLP-1) secretion and glucose tolerance in patients with type 2 diabetes with chronic liver disease. Research design and methods Japanese patients with type 2 diabetes (glycated hemoglobin (HbA1c) levels ≥7.0%) and chronic liver disease were included in this study. Sixteen patients (HbA1c level, 7.2%±...

The present study was designed to examine the hepatoprotective effects of curcumin (CMN), resveratrol (RSV) and ursodeoxycholic acid (UDCA) against ethinylestradiol and chlorpromazine -induced intrahepatic cholestasis. Ethinylestradiol (EE) and chlorpromazine HCl (CPZ) were administered orally once daily simultaneously with the tested compounds for one week. At the end of the experimentation pe...

UDCA renders bile acid composition more hydrophilic, shifts the bile-acid/phospholipid ratio towards less toxic effects and, thus, might protect against hepatobiliary injury by hydrophobic bile acids. UDCA is a constituent of human bile in a low concentration of 3% of total bile acids. It is the major bile acid of the bile of black bears and has been used for centuries in traditional Chinese me...

Primary biliary cirrhosis (PBC) is a chronic, cholestatic liver disease that is characterized by progressive immune mediated destruction of the intrahepatic bile ducts. Over time, fibrosis extends out of the portal tracts and progresses to cirrhosis. Neither the etiology nor the pathogenesis are well understood; however, most of the current evidence suggests that it is an autoimmune condition t...

BACKGROUND To exam the biochemical, obstetric management and pregnancy outcome in women with intrahepatic cholestasis of pregnancy (ICP) and treatment with ursodeoxycholic acid (UDCA). METHODS Pregnancy outcome in patients with ICP (N = 307) was studied and patients treated with UDCA (N = 208) vs. no UDCA were compared. The data of the antenatal visits, deliveries and neonatal outcome of 307 ...

Primary biliary cirrhosis (PBC) is a chronic cholestatic, progressive inflammatory liver disease with a suspected autoimmunological pathogenesis. The disease is typically diagnosed in women at an age between 30 and 65 years and has a prevalence of up to 1 in 1000 women over the age of 40. The only approved medical therapy for PBC is ursodeoxycholic acid (UDCA) in a recommended dose of 13–15mg/k...

Ursodeoxycholic acid (UDCA) has been used to treat people with CFLD for years, and usually started in childhood or adolescence. This study aims assess the effect of stopping UDCA on Liver Function Tests (LFT’s) liver stiffness measurement (LSM) using ultrasound shear wave elastography adult patients CF-related disease (PwCFLD) under care All Wales Adult CF Centre (AWACFC). Clinical, laboratory ...