In neurodegenerative disorders, abnormally hyperphosphorylated and aggregated tau accumulates intracellularly, a mechanism which is thought to induce neuronal cell death. Methylene blue, a type of phenothiazine, has been reported to inhibit tau aggregation in vitro. However, the effect of methylene blue in vivo has remained unknown. Therefore, we examined whether methylene blue suppresses abnor...

Since but little work has been done on the innervation of the esophagus, it seemed to me that it might be both interesting and profitable to determine, by means of the inlru-&am methylene blue method, the arrangement and terminations of the nerves in this part of the digestive tract, to verify the results already gained by other methods and, so far as practicable, to compare the innervation of ...

Methylene blue has been shown to be neuroprotective in multiple experimental neurodegenerative disease models. However, the mechanisms underlying the neuroprotective effects have not been fully elucidated. Previous studies have shown that macroautophagy has multiple beneficial roles for maintaining normal cellular homeostasis and that induction of macroautophagy after myocardial ischemia is pro...

Atherosclerotic plaques that undergo rapid progression to stenosis are responsible of stroke or acute coronary syndrome. The vulnerability of the atherosclerotic plaque may be enhanced due to the presence of microcalcifications. Our aim was to analyze microcalcifications on epoxy resin-embedded semithin sections from bioptic samples of carotid endarterectomies. An original trichromic method con...

Tissue oxidases, especially xanthine oxidase, have been proposed as primary sources of toxic oxygen radicals in many experimental models of disease states. Among these, ischemia-reperfusion injury may be of the greatest clinical interest. In this paper we propose the use of methylene blue as a means of suppressing the production of superoxide radicals O2- by acting as an alternative electron ac...