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Calcium waves in membrane fusion hagolysosome fusion is a calcium dependent process. Now, Randall Worth and colleagues (University of Pennsylvania School of Medicine, Philadelphia, PA), and Howard Petty and colleagues (University of Michigan School of Medicine, Ann Arbor, MI) find that a three amino acid motif in the IgG receptor Fc RIIA causes a calcium wave traveling along the plasma membrane...
Dexmedetomidine is a new alpha2-agonist that received FDA approval in 1999 for use as a short-term (less than 24 h) sedativeanalgesic in the intensive care unit. The use of alpha2-agonists as anesthetics is not new since many alpha2-agonists are used in veterinary medecine to induce anesthesia. Clonidine, the prototype of alpha2agonists, has been synthesized in early 1970’s for its use as nasal...
Chloroquine (CHQ) is a cheap, relatively well tolerated drug initially developed for the treatment of malaria in the 1930s. CHQ has, however, since accrued a plethora of uses in the treatment and amelioration of several other diseases and conditions because of its lysosomotropic properties. It also has characteristic physiological and systemic effects. This review gives an overview of the histo...
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lj>0 i [ most of us, leisure means simply ( ^.. 'what we do with our spare time," \ pf0. '^mediately, we are up against the o.L 'em of what really is "spare time." f. ine uFe can therefore have as wide a An.lng as work itself. sentristotle claimed that leisure repre^ ^isim "satisfaction the truly 1 1rstanding, which is man's highest Paj ' So the artist...
Jet nebulisers are used to deliver a wide range of drugs as aerosols. The British National Formullarv lists not only six bronchodilator solutions in doses up to 10 mg (available in single dose ampoules, multidose vials, or both), but also one corticosteroid, one prophylactic agent (sodium cromoglycate), and two mucolytics as being suitable for nebulisation.' In addition, nebulisers have been us...
We study the diierent manifestations of convexity in classiier-constructing machine learning algorithms. Two principal ways to apply the consequences of the convexity of the evaluation function to enhance numerical domain partitioning exist: it enables static and dynamic pruning of partition candidates. Numerical attribute handling is a potential time-consumption bottleneck in classiier learnin...
This chapter presents a variety of applications of norms. These applications include governance in sociotechnical systems, data licensing and data collection, understanding software development teams, requirements engineering, assurance, natural resource allocation, wireless grids, autonomous vehicles, serious games, and virtual worlds. 1998 ACM Subject Classification I.2.11 Distributed Artific...
Defenders of the prosentential theory of truth claim that the English language contains prosentences which function analogously to their better known cousins – pronouns. Statements such as ‘That is true’ or ‘It is true’, they claim, inherit their content from antecedent statements, just as pronouns inherit their reference from antecedent singular terms. Prosentential theorists claim that the co...
Despite the long history of plant usage, the economic values of the highly diverse Croatian vascular flora (5516 taxa) were never investigated. For the purpose of a survey of the useful and harmful species, the available information was accumulated in the Flora Croatica Database (FCD) and a new database module for economic botany has been developed. An Economic Botany Standard was adopted on th...
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