MR imaging with retrobulbar anesthesia was performed in eight patients with uveal melanoma. Injection of 2 mL prilocain hydrochloride in 2% epinephrin into the eye muscle cone resulted in improved image quality in seven patients, without side effects. Ocular MR imaging can be indicated to clarify indeterminate sonographic findings in cases of extrascleral growth or to exclude optic nerve invasi...

Uveal melanoma is the most common malignancy of the eye, but little is known about its underlying genetic defects. Melanomas of uveal origin, unlike those of the skin, are rarely familial and have not been linked consistently to mutations in tumor suppressor genes. Here, we investigated the Rb pathway in uveal melanoma. Most tumors displayed strong immunostaining for Rb and p16, suggesting that...

Injection of pine pollen into the vitreous of guinea pigs previously sensitized with Freund's adjuvant and pine pollen intradernialhj and intraperitoneally restdted in a disseminated granulomatous inflammatory process involving the entire uveal tract. Moderate or large doses of steroids (2 to 8 mg. per kilogram per day of prednisolone) diminished the reaction when given 1 to 2 weeks after the c...

Multifocal choroiditis with overlying retinal detachment occurs after carotid injection of certain bacteria in dogs. The ocular lesions occur mainly in the tapetal area of the retina, correlate with microabscesses in the inner choroid and subretinal space, and occasionally occur in the inner retina and anterior uveal tract. The major pathophysiologic factor involved in the dog model of septic c...

Fuchs' theory Ernst Fuchs, who first described this disease in 1906, assumed that the syndrome was caused by a noxious factor of unknown origin, which was active from fetal or early postnatal life.' First, the normal development of uveal pigmentation would be inhibited, resulting in heterochromia (Fig 1). Later, the eye would respond to this pathological agent by a low grade inflammation. Many ...

PURPOSE. It is known that the pRb pathway cell-cycle inhibitor p16 plays a significant role in cutaneous melanoma and that alteration of p16, which resides within the 9p21-22 locus that also contains p15 and p14, may occur in up to one third of uveal melanomas. The absence of TGF responsiveness noted in cultured uveal melanoma cells also suggests that the TGF pathway plays a role in the formati...

Methods: From lYYO-1993, 38 cases of unilutcrdl retinoblastoma were treated in National Cancer Center Hospital in Tokyo. Except for Y eyes with absolute glaucoma, suspicious extraocular extension or refusal of conservative therapy, all of them were treated conservatively. Ocular hypcrthetmia using Lagendijk’s applicator wwc combined with radiotherapy, selective t,, ophthalmic aaerial injection ...

Follow up information was retrieved on 111 patients who underwent enucleation for uveal melanoma between 1964 and 1987, allowing a minimum postoperative period of 5 years. Univariate survival analysis was carried out using Kaplan-Meier curves and the differences between the curves were analysed with the Mantel-Cox test. Multivariate analysis used the Cox proportional hazards model. Univariate a...

The benzophenanthridine alkaloids sanguinarine, chelerythrine and chelidonine were reported previously to provoke cell death in a variety of tumor cells suggesting their potential application as anticancer agents. Here we tested their effects on a primary human uveal melanoma cell line, OCM-1. Flow cytometric analysis of annexin V binding/PI exclusion and DNA fragmentation disclosed that all th...

Seven uveal melanomas were stained for gamma enolase by an immunoperoxidase PAP (peroxidase-antiperoxidase) technique, and biochemical assays were carried out on tissue homogenates. A correlation between the biochemical assay and the immunoperoxidase staining was demonstrated. Two tumours with the highest biochemical assays showed positive staining for the enzyme, and 2 tumours with the lowest ...