The effect of short-term and long-term in vivo exposure to cadmium on the morphology of common carp erythrocytes was evaluated, and comparison of in vitro toxicity of various cadmium salts to these cells was also done. Juvenile carps were subjected to 3 h exposure at 6.5 mg/l or to a 4 week exposure at 0.65 mg/l of cadmium. Full blood was incubated for 2 h with cadmium chloride, sulfate, or nit...

The in vitro interaction between Treponema pallidum and Sf1Ep cells during treponemal replication was investigated by using transmission electron microscopy. The Sf1Ep cells grown on Teflon-treated cover slips after 12 days of cocultivation were fixed in situ, overlaid with agar, embedded, and vertically sectioned. Large numbers of treponemes were found extracellularly not only at the upper cel...

Cinnamomum verum, also called true cinnamon tree, is employed to make the seasoning cinnamon. Furthermore, the plant has been used as a traditional Chinese herbal medication. We explored the anticancer effect of cuminaldehyde, an ingredient of the cortex of the plant, as well as the molecular biomarkers associated with carcinogenesis in human colorectal adenocarcinoma COLO 205 cells. The result...

Studies were conducted to determine whether accumulation of the scrapie agent protein Sp33-37 in brain correlated with the appearance of the scrapie agent or with pathology. The concentrations of the scrapie agent and Sp33-37 were measured in purified fraction P5 isolated from hamster brains at weekly intervals after inoculation. The scrapie agent concentration in fraction P5 was approximately ...

The purpose of this study was to determine the effects of inhibitors of Rho kinase (ROK) and matrix metalloproteinases (MMPs) on angiogenesis and tumor growth and to evaluate ROK activity in human prostate cancer PC3 cells and endothelial cells (HUVECs). Vacuolation by endothelial cells and lumen formation, the earliest detectable stages of angiogenesis, were inhibited by the ROK inhibitor Wf-5...

OBJECTIVE To characterize clinical features of avian vacuolar myelinopathy (AVM) in American coots. DESIGN Case-control study. ANIMALS 26 AVM-affected American coots and 12 unaffected coots. PROCEDURES Complete physical, neurologic, hematologic, and plasma biochemical evaluations were performed. Affected coots received supportive care. All coots died or were euthanatized, and AVM status w...

The purpose of this work is to determine and describe the effects of subacute cyanide toxicity to goats. Eight female goats were divided into two groups. The first group of five animals was treated with 8.0 mg KCN kg(-1) body weight day(-1) for seven consecutive days. The second group of three animals was treated with water as controls. Complete physical examination, including observation for b...

Autophagy is the unique, regulated mechanism for the degradation of organelles. This intracellular process acts as a prosurvival pathway during cell starvation or stress and is also involved in cellular response against specific bacterial infections. Vibrio cholerae is a noninvasive intestinal pathogen that has been studied extensively as the causative agent of the human disease cholera. V. cho...

In this study, 60 males of albino rats (Rattus rattus) were tested to study the effect BV on kidney tissue at two doses 10 and 40 µg/kg times after 15 days. The sample included divided into groups; 20 for each group. These groups injected intraperitoneally according mentioned periods considered as a control results exhibited renal tubule dilation slight atrophy glomerular tuft in kidneys treate...