Hematopoietic myeloid progenitors released into the circulation are able to promote vascular remodeling through endothelium activation and injury. Endothelial injury is central to the development of pulmonary arterial hypertension (PAH), a proliferative vasculopathy of the pulmonary circulation, but the origin of vascular injury is unknown. In the present study, mice transplanted with BM-derive...

In the previous report, Meox1 was found to promote SMCs phenotypic modulation and injury-induced vascular remodeling by regulating the FAK-ERK1/2-autophagy signaling cascade (Wu et al., 2017) [1]. Here, we presented new original data on the involvement of Mesoderm/mesenchyme homeobox gene l (Meox1) in balloon-injury-induced neointima formation of rat. In rat carotid artery balloon injury model ...

a 15- year-old boy with history of bb gun injury to his left eye was referred to our center. his visual acuity was no light perception in the left eye. ocular findings were severe proptosis, conjunctival injection, and conjunctival vascular tortuosity. fundus examination revealed an extensive inferior chorioretinal scar compatible with chorioretinitis sclopetaria. a distinct bruit was detected ...

Major vascular injury following trauma is uncommon, however, it can result in extremely high mortality and morbidity, particularly if diagnosis or treatment are delayed. Physical examination has historically been the mainstay of diagnosis, and open repair the mainstay of treatment for these injuries. However, as advanced imaging technologies and endovascular treatment modalities become more com...

Osteopontin is known to play important roles in various diseases including vascular disorders. However, little is known about its expression and function in vascular adventitial fibroblasts. Adventitial fibroblasts have been shown to play a key role in pathological vascular remodeling associating with various vascular disorders. In this study, we measured activation of Osteopontin and its biolo...

OBJECTIVE Salsalate is a dimeric form of salicylic acid that has been shown to have anti-inflammatory activity and to reduce glucose levels, insulin resistance, and cytokine expression. However, the effect of salsalate on vascular injury has not been determined. The objective of this study is to investigate the effect of salsalate on vascular injury and repair in a rat model of carotid artery b...

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