Slow activation and rapid C-type inactivation produce inward rectification of the current-voltage relationship for human ether-a'-go-go-related gene (hERG) channels. To characterize the voltage sensor movement associated with hERG activation and inactivation, we performed an Ala scan of the 32 amino acids (Gly(514)-Tyr(545)) that comprise the S4 domain and the flanking S3-S4 and S4-S5 linkers. ...

The fourteen kinds of pressure-transmitting media were evaluated by the ruby fluorescence method at room temperature, 77 K using the diamond anvil cell (DAC) up to 10 GPa in order to find appropriate media for use in low temperature physics. The investigated media are a 1:1 mixture by volume of Fluorinert FC-70 and FC-77, Daphne 7373 and 7474, NaCl, silicon oil (polydimethylsiloxane), Vaseline,...

PURPOSE To evaluate wound contraction and the concentration of mast cells in skin wounds treated with 5% BPT essential oil-based ointment in rats. METHODS Twenty rats, male, of adult age, were submitted to skin surgery on the right (RA) and left antimeres (LA) of the thoracic region. They were divided into two groups: control (RA - wounds receiving daily topical application of vaseline and la...

Basic experiments have demonstrated that the effect of wound healing in moist environments is better than that in dry environments; therefore, research on moist dressing is the focus of wound healing research. 42 burn patients receiving treatment in Jiangsu Provincial People's Hospital were selected as experimental cases. Wound surface is divided into treatment group and control group using a s...

Objective: A powder jet deposition (PJD) process can be used to create a thick hydroxyapatite (HA) layer on the human tooth surface. The purpose of this exploratory trial was to evaluate the safety and efficacy of the hydroxyapatite layer formed by a new dental treatment system for cases of caries, dentin hypersensitivity, or discolored teeth. Methods: A single facility, non-blinded study compa...

For chronic fissure in ano, surgical excision and suture has been practised with surprisingly good results. A stay suture is inserted at the proximal and distal extremities of the fissure which is made prominent by tension on each stay. The fissure is then easily excised with the subjacent portion of the subcutaneous external sphincter. Two or three figure-of-eight sutures of fine nylon are pla...

Due to the emergence of antibiotic resistance in pathogenic microorganisms, it is urgent search for producers new antimicrobial metabolites. Actinomycetes are gram-positive mycelial bacteria that produce a large number antibiotics used medicine and agro-industrial complex. Currently, researchers focused on actinomycetes ecological niches such as freshwater marine reservoirs, zones with extreme ...

Purpose. To evaluate the intensity of healing an infected skin wound in rats using Trigonella foenum- graecum (Fenugreek) against background experimental steroid hyperglycemia. Materials and methods. The included study ( n = 20) were divided into two equal groups. First, a model hyperglycemia was created for all animals. Then same animals used to create models wound. first group (the main one) ...

Absorbance signals were recorded from cut single skeletal muscle fibers stained with the nonpenetrating potentiometric dye NK2367 and mounted in a three-vaseline-gap voltage clamp . The characteristics of the optical signals recorded under current and voltage-clamp conditions were studied at various wavelengths between 500 and 800 nm using unpolarized light . Our results indicate that the absor...