The pathophysiology of acute mountain sickness and high-altitude cerebral edema, the cerebral forms of high-altitude illness, remain uncertain and controversial. Persistently elevated or pathological fluctuations in intracranial pressure are thought to cause symptoms similar to those reported by individuals suffering cerebral forms of high-altitude illness. This review first focuses on the basi...

Aquaporin-4 (AQP4) is expressed in astrocytes throughout the central nervous system, particularly at the blood-brain and brain-cerebrospinal fluid barriers. Phenotype analysis of transgenic mice lacking AQP4 has provided compelling evidence for involvement of AQP4 in cerebral water balance, astrocyte migration, and neural signal transduction. AQP4-null mice have reduced brain swelling and impro...

In this issue of the AJNR, Ito et al report a case in which hypertension, convulsions, visual disturbances, and unconsciousness developed while the patient underwent therapy with cisplatin. T2-weighted MR images showed bilateral increased signal intensity within the white matter of the frontoparietal lobes, which reversed after antieplieptic therapy and control of hypertension. The MR findings ...

We developed a closed-skull model of freeze injury-induced brain edema, a model classically thought to produce vasogenic edema, and observed the natural course of changes in edema and blood flow using xenon-enhanced computed tomography (CT) in five rhesus monkeys before and for up to 6 h post insult. Intracranial pressure (ICP) gradually rose throughout the duration of the experiment. CT scans ...

The mechanisms leading to cerebral malaria (CM) are not completely understood. Brain edema has been suggested as having an important role in experimental CM. In this study, CBA/CaH mice were infected with Plasmodium berghei ANKA blood-stage and when typical symptoms of CM developed on day 7, brain tissues were processed for electron-microscopic and immunohistochemical studies. The study demonst...

Abstract INTRODUCTION Corticosteroids are commonly used preoperatively in patients with brain metastases to mitigate symptoms related vasogenic peritumoral edema (PTE). Though these tumors highly prevalent, surprisingly few studies have examined the effect of steroids on PTE evident MRI. We investigated whether steroid administration was associated greater reduction metastasis compared steroid-...

The prevention of BBB breakdown and the subsequent vasogenic edema are important parts of the medical management of ischemic stroke. The purpose of this study was to investigate the ischemic tolerance effect of Rosmarinus officinalis leaf hydro-alcoholic extract (RHE). Five groups of animals were designed: sham (underwent surgery without MCAO) and MCAO groups, the MCAO groups were pretreated or...

introduction: myelograghy is a process of instilling contrast medium to the subarachnoid space for evaluating the spinal column by radiography. there are various contrast solutions for different radiographic studies but not all of them are suitable for spinal column evaluation. conclusions: our subject recovered completely without any sequelae after receiving appropriate treatment in a multidis...

massive cerebral infarction is often accompanied by early death, secondary to brain edema and trans-tentorial herniation. several reports indicate beneficial effects of decompressive craniectomy in this situation, but the efficacy of this procedure is still a matter of debate. a n experimental study in a period of3 years was done on2 3 patients with brain edema due to massive cerebral infarctio...

Posterior reversible encephalopathy syndrome (PRES) is a clinicoradiological syndrome in which patients present with an acute or subacute clinical presentation of seizures, visual disturbances, headache, and altered mental status. The pathophysiology of PRES may be explained by endothelial dysfunction that leads to transudation of fluids and protein, resulting in vasogenic cerebral edema. PRES ...