BACKGROUND Succinylcholine has been the neuromuscular blocking drug of choice for laryngoscopy and intubation, but it has several adverse effects. Nondepolarizing neuromuscular blocking drugs are good alternative provided their onset of action is hastened. Priming technique and use of ephedrine or MgSO4 pretreatment is good options. AIMS To compare the effects of priming and ephedrine pretrea...

BACKGROUND Resistance to non-depolarizing neuromuscular blocking agents induced by sepsis is associated with the qualitative change in the nicotinic acetylcholine receptor (nAChR). This study aims to investigate the effects of sepsis on the neuromuscular block properties of vecuronium in relation to the expression of fetal and neuronal α7 type nAChR. METHODS Male Sprague-Dawley rats were rand...

UNLABELLED The adverse reactions that may occur during a surgical intervention are of concern to anesthesiologists and allergists due to the civil responsibility they entail and the increased demand for healthcare in allergology units. The aim of the present study was to determine the prevalence of adverse reactions in our setting (Island of Lanzarote) and modifications to immune response media...

CORRESPONDENCE ATRACURIUM OR VECURONIUM FOR MHS PATIENTS? Sir,—I am writing in regard to comments made by Hunter [1] in her review entitled "Adverse Effects of Neuromuscular Blocking Drugs ", on the use of vecuronium and atracurium in malignant hyperthermia-susceptible (MHS) patients. She states that "satisfactory use of both agents has been reported in patients susceptible to malignant hyperpy...

Vecuronium-induced neuromuscular blocks in 42 ASA physical status I and II females were antagonized with atropine and equipotent doses of edrophonium, neostigmine and pyridostigmine. Recovery characteristics including speed of reversal, dysrhythmias and mean arterial pressure changes were studied. Edrophonium was associated with the fastest neuromuscular recovery. No clinically significant card...

BACKGROUND AND OBJECTIVES Anesthetic drugs and material wastage are common in operation rooms (ORs). In this era of escalating health-care expenditure, cost reduction strategies are highly relevant. The aim of this study was to assess the amount of daily intravenous anesthetic drug wastage from major ORs and to estimate its financial burden. Any preventive measures to minimize drug wastage are ...

We have studied the dose-response relationship for neostigmine in 36 adult (ages 18-50 yr) and 36 elderly (ages > 70 yr) subjects during antagonism of neuromuscular block induced by vecuronium. All patients received vecuronium 0.08 mg kg-1 and neuromuscular block was monitored mechanomyo-graphically using the train-of-four (TOF) mode of stimulation. Six patients of each age group were allocated...