نتایج جستجو برای: vhh
تعداد نتایج: 516 فیلتر نتایج به سال:
A cDNA Immunization Strategy to Generate Nanobodies against Membrane Proteins in Native Conformation
Nanobodies (Nbs) are soluble, versatile, single-domain binding modules derived from the VHH variable domain of heavy-chain antibodies naturally occurring in camelids. Nbs hold huge promise as novel therapeutic biologics. Membrane proteins are among the most interesting targets for therapeutic Nbs because they are accessible to systemically injected biologics. In order to be effective, therapeut...
Current Protocols is issuing corrections for the following Protocol article. Gavira-O'Neill, C. E., Dong, J.-X, & Trimmer, J. S. (2020). Development, screening, and validation of camelid-derived nanobodies neuroscience research. in Neuroscience, 94, e107. https://doi.org/10.1002/cpns.107 In above referenced article, errors Basic 2 3 are being corrected. 2, Materials List, concentration primers ...
Gamma delta T cells expressing the Vg9Vδ2 T cell receptor (TCR) are the most predominant gδ-T cell subset in peripheral blood accounting for approximately 1-5 % of all T cells. Vg9Vδ2 T cells recognize phosphoantigens (pAg) such as isopentenyl pyrophosphate (IPP), a naturally occurring pAg that can accumulate in tumor cells, resulting in activation, cytokine release and anti-tumor activity of V...
Bacillus anthracis, the causative agent of anthrax, secretes three polypeptides, which form the bipartite lethal and edema toxins (LT and ET, respectively). The common component in these toxins, protective antigen (PA), is responsible for binding to cellular receptors and translocating the lethal factor (LF) and edema factor (EF) enzymatic moieties to the cytosol. Antibodies against PA protect ...
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