Since direct analysis of many aspects of spliceosomal function is greatly hindered by the daunting complexity of the spliceosome, the development of functionally validated simple model systems can be of great value. The critical role played by a base-paired complex of U6 and U2 snRNAs in splicing in vivo suggests that this complex could be a suitable starting point for the development of such a...

Cobalt-catalyzed activation of methylthio-substituted N-heterocycles facilitates either cross-coupling reactions with aryl- or benzylzinc compounds or synthesis of the corresponding zinc compounds.

Expression of eukaryotic mRNAs requires the collaboration of a host of RNA processing factors acting upon the transcript. Berg et al. describe how a pre-mRNA splicing factor modulates the activity of the polyadenylation machinery to regulate mRNA length, with important implications for isoform expression in activated neuronal and immune cells.

In this paper, a closed-form identification of possibly nonrninimum phase multichannel moving average (MA) processes is derived by exploiting the eigenstructures of the observation cumulant matrices using ~the ESPRIT algorithm. The proposed approach allows the combination of statistics of different orders for better performance and offers reduced computation complexity when compared with existi...

The complexity and routability of layout depends on the number of layers, which can be used for the completion of interconnections. The global routing can be solved by graph based techniques. Efficient 3D routing methods are efficient to minimize the via overflows and total number of vias. The minimization methods rip-up and reassignment for a integer programming based layer assignment. Benchma...

A methodology is proposed to characterize through silicon via (TSV) induced noise coupling in threedimensional (3D) integrated circuits. Different substrate biasing schemes (such as a single substrate contact versus regularly placed substrate contacts) and TSV fabrication methods (such as via-first and via-last) are considered. A compact π model is proposed to efficiently estimate the coupling ...

During meiosis, homologous chromosomes (homologs) perform reciprocal exchanges (crossovers) at a high frequency. Crossovers display interference, i.e. their spacing is more even than would be expected if they were placed randomly along the chromosomes. Concomitantly with crossover formation, synaptonemal complexes (SCs) appear between homologs: each chromosome forms an axial structure, the axia...

In the current state-of-art beat tracker, it is common that a specific algorithm do the best on particular kind of audio. For example, the algorithm based on two-fold dynamic programing have sequential 1 st place on time-varying-tempo MAZ dataset of MIREX audio beat tracking. This study proposed a tempogram-sensing-vector (TSV) method to be adaptive to time-varying-tempo and stable-tempo excerp...

A new dissymmetrically disubstituted diiron dithiolate species, [Fe(2)(CO)(4)(κ(2)-P(Ph)(2)N(Ph)(2))(μ-pdt)] (pdt = S(CH(2))(3)S), was prepared by using a flexible cyclic base-containing diphosphine, 1,3,5,7-tetraphenyl 1,5-diaza-3,7-diphosphacyclooctane (P(Ph)(2)N(Ph)(2) = {PhPCH(2)NPh}(2)). Preliminary investigations of proton and electron transfers on the diiron system have been done.