نتایج جستجو برای: vinca major
تعداد نتایج: 619955 فیلتر نتایج به سال:
When tumor cells are chronically treated with antitumor drugs such as vinca alkaloids or anthracyclines, they often acquire resistance not only to the same drugs but also to other antitumor drugs1~3). Although the mechanism of this pleiotropic drug resistance is not fully understood, decreased uptake and retention of doxorubicin ( = adriamycin, ADM) and daunorubicin ( = daunomycin, DNR) in drug...
Application of green walls still has not attracted interest among the contractors and people, and this can be due to poor growing performance of the plants on these systems. This study investigated the effect of four growing media types (30% cocopeat + 65% perlite + 5% vermicompost, 30% soil + 65% perlite + 5% vermicompost, 30% mushroom compost + 65% perlite + 5% vermicompost and regular soil a...
نواری گلی (Catharanthus roseus L.)، یکی از گیاهان دارویی مهم در دنیاست که بومی ماداگاسکار میباشد. آلکالوئیدهای این گیاه تقسیم میتوز را مهار میکنند. از جنس نواری (Vinca) تنها گونه نواری علفی (Vinca herbaceae L.) در مناطق شمال ایران میروید. در این پژوهش آلکالوئیدهای نواری گلی و نواری علفی جدا و اثر ضدمیتوزی آنها بر سلولهای مریستم ریشه پیاز بررسی شد. آلکالوئیدهای دو گونه نواری با حلالهای مخت...
The synthetic investigation of biologically active natural compounds serves two main purposes: (i) the total synthesis of alkaloids and their analogues; (ii) modification of the structures for producing more selective, more effective, or less toxic derivatives. In the chemistry of dimeric Vinca alkaloids enormous efforts have been directed towards synthesizing new derivatives of the antitumor a...
Vinorelbine (5'-noranhydrovinblastine) is a new semisynthetic antineoplastic vinca alkaloid which interfers with axonal transport, inducing spiralisation of axonal microtubules and resulting in peripheral neurotoxicity. A prospective detailed neurological and electrophysiological evaluation was performed in 23 patients treated with 25 mg vinorelbine a week. All patients developed a sensory-moto...
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