A reliable method of producing tlirombosis of the inferior vena cava in dogs is described. This consists of placing a segment of umbilical tape across the lumen of the vein and sewing it in place without interfering with blood flow. In the control animals gross thrombi were not usually present in the immediate postoperative period but were demonstrated after 24 hours. By the 7th postoperative d...

Venomous snakebites are lethal and occur frequently worldwide each year, and receiving the antivenom antibody is currently the most effective treatment. However, the specific antivenom might be unavailable in remote areas. Snakebites by Viperidae usually lead to hemorrhage and mortality if untreated. In the present study, challenges of rattlesnake (Crotalus atrox) venom markedly increased the c...

Photo 1: A Russell's viper (Daboia russelii) basks in the low branches of a tree Karnataka, India, water canal located right next to an agricultural field. credit: Xavier Glaudas. This photograph illustrates article “Proximity between humans and highly medically significant snake, viper, tropical rural community” by Glaudas published Ecological Applications. https://doi.org/10.1002/eap.2330

A disintegrin and metalloproteinase (ADAM) family proteins constitute a major class of membrane-anchored multidomain proteinases that are responsible for the shedding of cell-surface protein ectodomains, including the latent forms of growth factors, cytokines, receptors and other molecules. Snake venom metalloproteinases (SVMPs) are major components in most viper venoms. SVMPs are primarily res...

Case summary A 4-year-old female spayed, indoor/outdoor domestic mediumhair cat presented with multiple bleeding puncture wounds and hemorrhagic shock. The cat was diagnosed with suspected pit viper envenomation based on the location and appearance of the bite wounds, as well as the presence of severe coagulopathy with prolonged activated coagulation time (762 s), which responded to antivenom a...

The effects of various viperid and elapid venoms on the cellular biology of tumour-associated microvascular endothelial cells (TAMECs) were determined in the current study using cells isolated from a rat mammary adenocarcinoma. Previous studies to determine the effects of snake venoms on endothelial cells in vitro have in the main been performed on either human umbilical vein endothelial cells ...

The viper is one of India's most commonly encountered poisonous snakes and envenomation following viper bite usually leads to consumption coagulopathy. Clinical manifestations most frequently include external and internal bleeding. In the setting of viper envenomation, large-vessel thrombosis is a very rare occurrence. Also, bilateral anterior cerebral artery infarction, when unrelated to anato...

Architectural design and analysis of VIPER, a VLIW processor designed to take advantage of instruction level parallelism, are presented. VIPER is designed to take advantage of the parallelizing capabilities of Percolation Scheduling. The approach taken in the design of VIPER addresses design issues involving implementation constraints, organizational techniques, and code generation strategies. ...

This paper describes a simulation platform for embedded software named ViPER (Virtual Platform and Environment Runtime). ViPER is oriented toward (but not limited to) systems of the automotive domain. It allows to model and simulate distributed embedded hardware platforms in order to ease the early development stages of the embedded software. Each node of the system is virtualized in a process ...