نتایج جستجو برای: viral inactivation
تعداد نتایج: 197344 فیلتر نتایج به سال:
UNLABELLED By selecting pseudorabies virus (PrV) as a model virus, this study assessed the feasibility of applying viral inactivation strategies to manufacturing medicinal products from the milk of transgenic sows. The efficacy of heat, acidic/alkaline and detergent treatments was also evaluated with respect to their ability to inactivate PrV in milk samples. Experimental results indicate that ...
The production of two reactive oxygen species through UV photosensitization of polyhydroxylated fullerene (fullerol) is shown to enhance viral inactivation rates. The production of both singlet oxygen and superoxide by fullerol in the presence of UV light is confirmed via two unique methods: electron paramagnetic resonance and reduction of nitro blue tetrazolium. These findings build on previou...
The mechanism of the antiviral activity of hypericin was characterized and compared with that of rose bengal. Both compounds inactivate enveloped (but not unenveloped) viruses upon illumination by visible light. Human immunodeficiency and vesicular stomatitis viruses were photodynamically inactivated by both dyes at nanomolar concentrations. Photodynamic inactivation of fusion (hemolysis) by ve...
The correlation between the detection of murine norovirus 1 RNA by real-time reverse transcription-PCR and the infectivity by plaque assay before and after heat exposure (80 degrees C) was examined. No correlation was found in the current study. Moreover, heat inactivation had a much stronger detrimental effect on virus infectivity than on the integrity of the viral genome.
Genetic strategies for perturbing activity of selected neurons hold great promise for understanding circuitry and behavior. Several such strategies exist, but there has been no direct demonstration of reversible inactivation of mammalian neurons in vivo. We previously reported quickly reversible inactivation of neurons in vitro using expression of the Drosophila allatostatin receptor (AlstR). H...
In a recent article, we found that Tribbles pseudokinase 3 (TRIB3) plays a tumor suppressor role and that this effect relies on the dysregulation of the phosphorylation of v-akt murine thymoma viral oncogene homolog (AKT) by the mammalian target of rapamycin complex 2 (mTORC2 complex), and the subsequent hyperphosphorylation and inactivation of the transcription factor Forkhead box O3 (FOXO3).
INTRODUCTION: Viral and bacterial transmission are possible adverse outcomes of utilizing banked tissues for transplantation. Concerns that current freezing and storage practices may not be adequate to inactivate retroviruses were substantiated by recent animal model studies. These studies documented viral transmission from retrovirus-infected, transplanted allogeneic cortical and cancellous bo...
BACKGROUND The ongoing Zika virus (ZIKV) outbreak in the Americas has also raised concerns around the potential for ZIKV transmission via blood products. Plasma-derived products are considered safe, because effective viral-inactivation and removal methods are implemented in their manufacturing processes. However, a recent study has indicated that ZIKV is "thermally stable" compared with the clo...
the AxSYM, which showed an increase to 122%. From these data it is tempting to speculate that the Triton X-100 inactivation treatment could be useful for most commercial assays on high-throughput analyzers. However, it may well be that certain assays are more influenced by the presence of 1 mL/L Triton X-100 than others. These data suggest that it is possible to protect laboratory workers while...
introduction: the aim of this study was to evaluate the effect of dentin on the antifungal activity of gray and white-colored mta (gmta, wmta) using a tube-dilution test. materials and methods: mta preparations were tested freshly mixed and after 24h on candida albicans (ca). the experiment was performed in 24-well culture plates. fifty wells were used and divided into four experimental groups ...
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