Mounting evidence suggests the interaction between stress and genetics contribute to the development of depressive symptoms. Currently, the molecular mechanisms mediating this process are poorly understood, hindering the development of new clinical interventions. Here, we investigate the interaction between neuropsin, a serine protease, and chronic stress on the development of depressive-like b...

The pathogen safety of plasma derivative and labile blood components has been dramatically enhanced over the last 25 years through the implementation of nucleic acid testing (NAT) technologies that effectively screen out units with high virus titers. Additionally, the incorporation of pathogen inactivation (PI) and removal steps into the manufacturing processes of plasma-derived medicinal produ...

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A device was designed to deliver a constant source of given concentrations of ozone to fluids containing human immunodeficiency virus type 1 (HIV-1). Ozone was found to inactivate HIV-1 virions in a dose-dependent manner. Greater than 11 log inactivation was achieved within 2 hours at a concentration of 1,200 ppm ozone. Similar concentrations of ozone had minimal effect on factor VIII activity ...

Mycotoxins such as Citrinin are small toxic molecules produced by a great variety of microorganism, which encompass several classes of secondary metabolites with no common chemical structure or mode of action. Citrinin produces by different species of Penicillium. Today, the cold atmospheric pressure plasma (CAPP) method has a potential for mycotoxin detoxification. In this study, a new and pro...

HIV entry to host cells begins with binding of the viral envelope protein to CD4 molecules on the host cell surface. This binding initiates conformational changes in the envelope protein that result in binding to a coreceptor (CCR5 or CXCR4), exposure of a previously hidden domain in the viral protein, insertion of a viral fusion peptide into the host-cell membrane and fusing the viral and cell...

Circulating enzymes may be inactivated in the plasma and the inactive breakdown products may be hydrolyzed in the lumen of the small intestine. Evidence for this mechanism was based upon previous studies with 125I-labeled lactate dehydrogenase-5, and here similar studies with radioiodinated lactate dehydrogenase-1 are reported, to determine whether this isoenzyme is similarly catabolized. The p...

Infectious SARS-CoV-2 can be recovered from the oral cavities and saliva of COVID-19 patients with potential implications for disease transmission. Reducing viral load in patient using antiviral mouthwashes may therefore have a role as control measure limiting virus spread, particularly dental settings. Here, efficacy inactivation by seven commercially available range active ingredients were ev...