Obesity is a low-grade chronic inflammatory disease associated with an increased number of macrophages (adipose tissue macrophages) in adipose tissue. Within the adipose tissue, adipose tissue macrophages are the major source of visfatin/pre-B-cell colony-enhancing factor/nicotinamide phosphoribosyl transferase. The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma) e...

BACKGROUND There is an increasing interest in the role of adipocytokines in cardiovascular pathophysiology. AIM The aim of the study was to compare visfatin levels, a novel adipokine, in patients with heart failure (HF) due to the left ventricular systolic dysfunction with those in age- and body mass index (BMI) - matched healthy controls in relation to the parameters of glucose metabolism an...

conclusions our findings indicated a lower level of both omentin-1 and igf-1 in women with mets; this might play a role in the pathogenesis of mets. furthermore, the main finding of the current investigation was the association between omentin, visfatin and igf-1; however determining the molecular mechanism of the observed relationships needs further studies. results significantly lower levels ...

background bioflavonoids are well known for their multi directional biologic activity including antidiabetic effect. it has been demonstrated that flavonoids can act as insulin secretagogue or insulin mimetic agents. objectives this experimental study was designed in arak university of medical sciences, arak, iran, to investigate the effects of biochanin a (a bioflavonoid) on fasting blood gluc...

INTRODUCTION Abdominal obesity (AO) is a risk factor of insulin resistance and its metabolic consequences. OBJECTIVES The aim of the study was to assess the associations between adiponectin and visfatin levels, body fat (BF), abdominal and hip fat depots, blood lipid profile, insulin sensitivity surrogates, and AO. PATIENTS AND METHODS The study included 145 healthy, premenopausal (aged 20-...

BACKGROUND/AIMS In the current study we examined if the adipocytokine, visfatin, alters connexin-mediated intercellular communication in proximal tubule-derived epithelial cells. METHODS The effects of visfatin (10-200ng/mL) on cell viability and cytotoxicity in HK2-cells were assessed by MTT, crystal violet and lactate dehydrogenase assays. Western blot analysis was used to confirm expressio...

INTRODUCTION Visfatin, protein secreted by visceral adipose tissue, exerts insulin-mimetic actions. Visfatin concentration increases in patients with longer-standing diabetes type 2 with progressive b-cell dysfunction. Data about the role of visfatin in newly diagnosed glucose metabolism abnormalities are limited. Evaluation of visfatin concentration in patients with obesity, in relation to the...