Voltage-dependent persistent inward currents are thought to make an important contribution to the input-output properties of alpha-motoneurons, influencing both the transfer of synaptic current to the soma and the effects of that current on repetitive discharge. Recent studies have paid particular attention to the contribution of L-type calcium channels, which are thought to be widely distribut...

This paper presents high boost isolated dc-dc converter with closed loop control to provide high voltage regulation control suitable for renewable energy source. The circuit consists of active clamp circuit and boost converter with isolated transformer. The circuit employs capacitors are charged in parallel and discharged in series by isolated transformer inductors. The active clamp circuit is ...

The main objective of this paper, a bidirectional dc–dc converter with duel coupled inductor is proposed. In the boost mode, two capacitors are parallel charged and series discharged by the coupled inductor. Thus, high step-up voltage gain can be achieved with an appropriate duty ratio. The voltage stress on the main switch is reduced by a passive clamp circuit. Therefore, the low resistance RD...

We examined the effects of mechanical stress, induced by a stream of bath solution, on evoked action potentials, electrical excitability, and Ca2+ currents in rat dorsal root ganglion neurons in culture with the use of the whole cell patch-clamp technique. Action-potential duration was altered reversibly by flow in 39% of the 51 neurons tested, but membrane potential and excitability were unaff...

Crayfish opener muscle fibers provide a unique preparation to quantitatively evaluate the relationships between the voltage-gated Ca2+ (ICa) and Ca2+-activated K+ (IK(Ca)) currents underlying the graded action potentials (GAPs) that typify these fibers. ICa, IK(Ca), and the voltage-gated K+ current (IK) were studied using two-electrode voltage-clamp applying voltage commands that simulated the ...

Identifiability analysis of a single Hodgkin–Huxley (HH) type voltage dependent ion channel model under voltage clamp circumstances is performed in order to decide if one can uniquely determine the model parameters from measured data in this simple case. It is shown that the two steady-state parameters (m1 , h1) and the conductance (g) are not globally identifiable together using a single step ...

Atomic-scale models on the gating mechanism of voltage-gated potassium channels (Kv) are based on linear interpolations between static structures of their initial and final state derived from crystallography and molecular dynamics simulations, and, thus, lack dynamic structural information. The lack of information on dynamics and intermediate states makes it difficult to associate the structura...