Introduction: 2D spatial selective RF pulse [1] is able to generate arbitrarily shaped excitation pattern, while parallel transmission [2] offers additional degrees of freedom to shorten the pulse width and reduce SAR. Both techniques have benefited the single and multi-voxel MR-spectroscopy [3, 4]. Recent years, sparse pulses [5, 6] have been developed to shorten the excitation duration by usi...

Functional magnetic resonance imaging (fMRI) studies are broken up into runs (or 'sessions'), frequently selected to be long to minimize across-run signal variations. For investigations that use multi-voxel pattern analysis (MVPA), however, employing many short runs might improve a classifier's ability to generalize across irrelevant pattern variations and detect condition-related activity patt...

We describe the optimal high-level postprocessing of single-voxel (1)H magnetic resonance spectra and assess the benefits and limitations of automated methods as diagnostic aids in the detection of recurrent brain tumor. In a previous clinical study, 90 long-echo-time single-voxel spectra were obtained from 52 patients and classified during follow-up (30/28/32 normal/non-progressive tumor/tumor...

OBJECTIVES To investigate the specific pattern of cerebral blood flow (CBF) in subjects with idiopathic normal pressure hydrocephalus (iNPH) using voxel-based analysis. METHODS N-isopropyl-p-[123I]iodoamphetamine (IMP) single photon emission computed tomography (SPECT) images were performed in 30 iNPH patients, who met probable iNPH criteria, 30 Alzheimer disease (AD) patients and 15 normal c...

Understanding emotions in others engages specific brain regions in temporal and medial prefrontal cortices. These activations are often attributed to more general cognitive 'mentalizing' functions, associated with theory of mind and also necessary to represent people's non-emotional mental states, such as beliefs or intentions. Here, we directly investigated whether understanding emotional feel...

Norman et al. [1] recently reviewed the use of multi-voxel pattern analysis (MVPA) of fMRI data. They provided examples that showed that patterns of activation across a set of voxels can contain far more information about mental states than the more typically used univariate approach. Patterns of fMRI activation can be used to discriminate cognitive states (sometimes called ‘mind reading’), to ...

Several functional areas are proposed to reside in human lateral occipitotemporal cortex, including the motion-selective human homolog of macaque area MT (hMT), object-form-selective lateral occipital complex (LO), and body-selective extrastriate body area (EBA). Indeed, several functional magnetic resonance imaging (fMRI) studies have reported significant activation overlap among these regions...

Recent studies of recognition memory indicate that subjects can strategically vary how much they rely on recollection of specific details vs. feelings of familiarity when making recognition judgments. One possible explanation of these results is that subjects can establish an internally directed attentional state ("listening for recollection") that enhances retrieval of studied details; fluctua...

Work in theoretical linguistics and psycholinguistics suggests that human linguistic knowledge forms a continuum between individual lexical items and abstract syntactic representations, with most linguistic representations falling between the two extremes and taking the form of lexical items stored together with the syntactic/semantic contexts in which they frequently occur. Neuroimaging eviden...