PTEN, a candidate tumor suppressor gene located at chromosome 10q23.3, has been shown to be mutated in approximately 40% of endometrial cancers. Such mutations have also been identified in endometrial hyperplasia, indicating that inactivation of the PTEN tumor suppressor gene is an early event in the genesis of some endometrial cancers. In this study, we have extended the analysis of PTEN in gy...

OBJECTIVES The purpose of this study is to statistically compare the mean ages of the patients with gynecologic cancer in our hospital during the 2000-2009 interval. MATERIAL AND METHODS The data was collected from the Histopathology Exams (HPE) registers. RESULTS Gynecologic cancer was discovered in 1244 cases: 731 cervical cancers, 392 uterine cancers, 82 ovarian cancers, 31 vulvar cancer...

Background Vulvar carcinomas comprise almost 5% of all malignant tumors of the female genital tract [1]. Primary therapeutic approach is considered a radical surgery [2]. Infection and wound breakdown are the most common complications, these occur in approximately 40-60% of patients [3]. Objective to value the efficacy of platelet gel as support for reconstructive surgery in recurrent vulvar ca...

BACKGROUND Vulvar cancer is a relatively rare malignancy, which occurs most often in postmenopausal women. We have previously identified a geographic cluster of vulvar cancer in young Indigenous women living in remote communities in the Arnhem Land region of Australia. In this population, we investigated the prevalence of oncogenic human papillomavirus (HPV) infection in anogenital samples (vul...

BACKGROUND The cyclin-dependent kinase inhibitors p15(INK4b) and p57(KIP2) are important regulators of the cell cycle, and their abnormal expression has been detected in various tumors. However, little is known about the role of p15(INK4b) and p57(KIP2) in the pathogenesis of vulvar carcinoma, and the prognostic impact is still unknown. In our current study, we examined the expression of p15(IN...

A 40 years old woman, presented with vulvar trauma to vulvar region few months back. She gave history of fall on those lesions while working as a labourer. She was diagnosed as a case of Lymphangiectasia of vulva. It was a rare coincidence, so we are reporting this case.

Introduction Cutaneous T-cell lymphomas (CTCLs) or B-cell lymphomas of the vulva are rare, aggressive, and often prone to either delayed or misdiag-nosis. Other cutaneous diseases, such as lichen sclerosis, sexually transmitted diseases and dermatopathologies (Citarella et al., 2003) can mimic the presentation of these cutaneous lymphomas. Furthermore, most cases of lymphoma of the vulva are se...

Vulvar metastasis of urothelial carcinoma of the bladder is a very rare entity; few cases are reported in the English literature. In this paper, we describe the clinical and pathological characteristics, evolution, and treatment of a patient with vulvar metastasis of urothelial carcinoma of the bladder followed by a brief review of the reported cases in the literature.