Econazole-nitrate (EC) and ciclopirox-olamine (CI) are well known antifungal agents suitable for the treatment of many mycotic infections. Previous studies showed that both dissolution properties and consequently microbiological activities of econazole, with very low water solubility (about 3 μg/mL at 25°C), can be improved by complexation with natural cyclodextrins, particularly with β-CD3-5. ...

An intramolecular hydrogen bond between NH•••O2N in insecticide, imidacloprid (1), and its nitromethylene analog 15 was proved by NMR and IR spectra. That electron delocalization over their planar moieties was disrupted by alkylation at the imidazolidine nitrogen atom is demonstrated by the hypsochromic shifts in UV and deshielding effect in NMR spectra. Interestingly, the N-alkyl derivatives (...

Three N,N-dimethyl pradimicins were synthesized by reductive alkylation of pradimicins A, E and FA-2 and evaluated for antifungal activity, water solubility and acute toxicity in mice. They showed in vitro antifungal activity superior to pradimicin A. N,N-Dimethylpradimicins E and FA-2 showed great improvement in water solubility and animal tolerance. N,N-Dimethylpradimicin FA-2 was effective i...

Despite the frequent use of freon-22 (e.g. to measure pulmonary blood flow), there is no agreement on its solubility in water or body fluids. The values in the literature vary, often quoted without reference to measurement or identification as Ostwald or Bunsen coefficients. We used a Schölander apparatus and determined the Bunsen solubility coefficient (mlgas.(mlfluid.atmosphere)-1) at 37 degr...

The purpose of the present research work was to observe the effects of drug solubility on their release kinetics of water soluble verpamil hydrochloride and insoluble aceclofenac from hydrophilic polymer based matrix formulations. Matrix formulations were prepared by the direct compression method. The formulations were evaluated for various physical parameters. Along with the dynamics of water ...

The present work concerns with an investigation on the solubility of cis,cis-muconic acid dissolution in different polar solvents by characterizing and modeling the dissolution as a function of temperature. Water, ethanol, 2-propanol and acetic acid have been investigated as solvents in the range temperatures from a 298.15 to 348.15 K. Owing to the absence of cis,cis-muconic acid solubility...

The solubility of KNO3 in the mixed solvent (water 85%+methanol 15%) were determined by using solvent evaporating method at different temperatures (25, 30, 40, 50, 60 ;C). In addition the equilibrium constant of ion pair formation, KIP, for K+NO3 – ion-pair on the basis of Fuoss contact ion pair model was calculated. Upon choosing the extended Debye-Hückel model for estimating the mean activity...

The Hydrocortisone acetate (Figure 1) is a white crystalline powder; it melts at about 220°C with decomposition and is practically insoluble in water 1mg/100mL [2]. One method to overcome the poorly water solubility of HA is the use of cyclodextrins (CDs), which have been extensively studied [3]. CDs have been extensively used as complexing agents to improve the solubility of a variety of poorl...

The common practice of remediating metal contaminated mine soils with compost can reduce metal mobility and promote revegetation, but the effect of introduced or colonising earthworms on metal solubility is largely unknown. We amended soils from an As/Cu (1150 mg As kg(-1) and 362 mg Cu kg(-1)) and Pb/Zn mine (4550 mg Pb kg(-1) and 908 mg Zn kg(-1)) with 0, 5, 10, 15 and 20% compost and then in...

Self-emulsifying drug delivery systems (SEDDS) were prepared by dissolving Cremophor EL, Tween 20, Tween 80 and Span 80 (1% or 5%) in oils (Miglyol 812 or castor oil). Solubilities of three ophthalmic drugs, namely aciclovir, hydrocortisone and indomethacin were determined in these systems. In addition, the effect of a small amount of water (0.5% and 2%) on solubilization properties of the syst...