血友病の凝固検査の特徴はAPTT延長にある．APTT測定時に得られる経時的な光強度情報（透過率，吸光度，散乱光量など）に基づく凝固波形解析から，血友病診療に有用なさまざまな情報が得られる．光強度変化を相対化することにより，凝固第VIII因子，第IX因子（FVIII, FIX）機能に焦点を当て，形成されるフィブリンの質的あるいは量的な影響を補正することが可能であり，実際に活用され始めている．血友病の診断においては，FVIII活性やFIX活性の1％未満の微量測定，genotypeとphenotypeを反映した包括的凝固機能 “coagulotype” の判定，APTT延長要因についての効率的な識別，などに凝固波形解析が有用である．血友病の治療においては，半減期延長型凝固因子製剤，バイパス止血製剤，非凝固因子製剤のモニタリングへの応用が研究されている．凝固波形解析は臨床検査室レベルの全自動...

In this article, I examine the source of the photoplethysmograph (PPG), as well as methods of investigation, with an emphasize on amplitude, rhythm, and pulse analysis. The PPG waveform was first described in the 1930s. Although considered an interesting ancillary monitor, the "pulse waveform" never underwent intensive investigation. Its importance in clinical medicine was greatly increased wit...

A commercially available six-dimensional (6D) motion system was assessed for accuracy and clinical use in our department. Positional accuracy and respiratory waveform reproducibility were evaluated for the motion system. The system was then used to investigate the dosimetric consequences of respiratory waveform variation when an internal target volume (ITV) approach is used for motion managemen...

The amplitude of coupled noise is often used in estimating the crosstalk effect. Coupling noise-induced delay measures the impact of crosstalk on circuit performance. Efficient computation of worst case noise-induced delays are essential, because such calculations are performed a huge number of times during timing analysis. In this paper we analyze the problem of crosstalk noise-induced delay i...

Information on the glottal waveform is an important part of many speech applications. However, glottal waveform estimation remains one of the more inexact sciences of speech processing. The work presented here describes an enhancement to a recently presented algorithm by a new technique involving Rank-Based Glottal Quality Assessment (RB-GQA). The basic premise is to investigate potential measu...

The feasibility of the application with phase coded waveform to missile borne Millimetre Wave (MMW) Synthetic Aperture Radar (SAR) system was investigated. Based on theory analysis, the geometry model was simplified, the expression of the equivalent range and the Range-Doppler image formation algorithm were deduced simultaneously. The phase coded waveform is pulse compression signal, and it can...

The knowledge of glottal closure and opening instants (GCI/GOI) is useful for many speech analysis applications. A Pitchsynchronous waveform encoding of voice is one such application. In this paper, a dynamic programming is employed to solve for the global close/open phase segmentation based on the polynomial parametric waveform of the derivative glottal waveform and its quasi-periodicity. Not ...

seismic tomography is an imaging technique which creates maps of subsurface elastic properties such as p/s wave velocity, density and attenuation, based on observed seismograms and use of sophisticated inversion algorithms. amongst different acquisition geometries, seismic cross-hole tomography has a special position in geophysical surveys with many applications in hydrocarbons, coal and other ...

Changes in reservoir properties resulting from extracting hydrocarbons and injecting fluid are critical to optimize production. These properties can be characterized using waveform inversions of time-lapse seismic data. The conventional approach for analysis using waveform tomography is to take the difference of seismic inversion obtained using baseline and subsequent time-lapse datasets that a...

Recent development of airborne laser scanner systems allows for digitization and recording of the full-waveform, i.e. the received signal of the reflected laser pulse. In this paper, some visualizations and analysis of waveform data are presented. The purpose is to study how waveform data can be used to extract additional information. As a first step, 3D point data are extracted and parameteriz...