Anticancer chemotherapy is a successful treatment of tumor to k il l or to low the mult iplying rate of tumor cells. Although the immunomodulatory ef fect of single chemotherapy has been invest igated, the effects of combinatorial chemotherapy are i ll defined. Therefore the aim of this study was to evaluate effects of CTX and CIS alone or in combination as convent ional chemotherapeut ic drugs...

The aim of the present study was to find the clinical and hematological alterations in female rabbits exposed orally to Malathion and Cypermethrin at a dose of 75mg/kg body weight for seven days through gavage. Animals were divided into three groups i.e. A, B and C comprised of three rabbits each. Group A was considered as control. Group B was intoxicated with Malathion while C was Cypermethrin...

BACKGROUND We examined whether white blood cell (WBC) count levels within normal range, could be associated with hemoglobin A1c (HbA1c) levels. METHODS Among the 11,472 people (≥19 years of age) who participated in the 2011 to 2012 Korea National Health and Nutrition Examination, subjects with chronic disease or illness, including 807 patients with diabetes currently taking anti-diabetic medi...

To evaluate the effects of enterectomy on cellular and biochemical parameters of blood and peritoneal fluid, an experiment was conducted using 10 Iranian crossbred male goats. Ten milliliter of blood and 1-1.5ml of peritoneal fluid were sampled from all animals prior to operation for the estimation of control values. Enterectomy was performed under local anesthesia. Blood and peritoneal fluid s...

Focal dermal hypoplasia (FDH) is a rare syndrome of severe developmental anomalies of the tissues and organs derived from ectoderm and mesoderm. Though data have suggested that FDH is an X-linked dominant trait associated with male hemizygote lethality, a hypothesis supported by the observation of three unrelated infants with FDH manifestations and de novo chromosome rearrangements involving Xp...

PURPOSE To establish the maximum dose intensity of cisplatin plus gemcitabine on a weekly or two-weekly schedule in patients with advanced non-small cell lung cancer (NSCLC). METHODS Patients with NSCLC stage IIIB or IV were randomized to receive weekly or two-weekly courses of gemcitabine on day 1 and cisplatin on day 2. An interpatient dose escalation scheme was used, and pharmacokinetics w...

Predictability of atmospheric variability is known to be limited owing to significant uncertainty that arises from intrinsic variability generated independently of external forcing and/or boundary conditions. Observed atmospheric variability is therefore regarded as just a single realization among different dynamical states that could occur. In contrast, subject to wind, thermal and fresh-water...

Isolated central nervous system (CNS) relapse is a rare, unpredictable event in patients with CML. Some studies have reported cases of isolated CNS relapse in CML [1-13]. However, very few studies have reported on isolated CNS relapse in the blast phase (BP) of CML in Korea [14, 15]. We report a case of BP CML with extramedullary lymphoblast proliferation in the CNS without evidence of disease ...

Stem cells possess the ability to home in and travel to damaged tissue when injected intravenously. For the cells to exert their therapeutic effect, they must cross the blood vessel wall and enter the surrounding tissues. The mechanism of extravasation injected stem cells employ for exit has yet to be characterized. Using intravital microscopy and a transgenic zebrafish line Tg(fli1a:egpf) with...

The major bcr-abl fusion gene is presently seen as the hallmark of chronic myeloid leukemia (CML) and presumably as the cause of its development. Accordingly, long-term disappearance of bcr-abl after intensive therapy is considered to be a probable cure of CML. The nested reverse transcriptase-polymerase chain reaction (RT-PCR) provides a powerful tool for minimal residual CML detection. The RT...