<b><i>Background:</i></b> Acute kidney injury (AKI) is a severe clinical syndrome, causing profound medical and socioeconomic burden worldwide. This study aimed to explore underlying molecular targets related the progression of AKI. <b><i>Methods:</i></b> A public database originated from NCBI GEO (serial number: GSE121190) well-established unbias...

Tuberculosis (TB) is still a leading cause of death worldwide. Treatments remain unsatisfactory due to an incomplete understanding the underlying host–pathogen interactions during infection. In present study, weighted gene co-expression network analysis (WGCNA) was conducted identify key macrophage modules and hub genes associated with mycobacterial WGCNA performed combining our own transcripto...

background: it is now well-demonstrated that histone demethylases play an important role in developmental controls, cell-fate decisions, and a variety of diseases such as cancer. lysine-specific demethylase 5d (kdm5d) is a male-specific histone demethylase that specifically demethylates di- and tri-methyl h3k4 at the start site of active genes. in this light, the aim of this study was to invest...

Preoperative radiochemotherapy is a promising therapeutic method for locally advanced rectal cancer patients. However, the response of colorectal (CRC) patients to preoperative radiotherapy varies widely. In this study, we aimed identify novel biomarkers that could predict tumors treatment using systems biology approach. We applied Weighted Gene Co-Expression Network Analysis construct co-expre...

Hepatocellular carcinoma (HCC) has a high incidence and mortality worldwide, and its carcinogenesis and progression are influenced by a complex network of gene interactions. A weighted gene co-expression network was constructed to identify gene modules associated with the clinical traits in HCC (n = 214). Among the 13 modules, high correlation was only found between the red module and metastasi...

conclusions in the present study, we identified a key gene rps16 and a significant module involved in ribosome biogenesis in eukaryotes that were related to neonatal sepsis, which might be potential biomarkers for early detection and therapy for neonatal sepsis. background the exact interacting factor that response to the infection for neonatal sepsis is still needed to urgently to be disclosed...

Non-steroidal anti-inflammatory drugs (NSAIDs) identified effective in many diseases. One of which is neurodegenerative diseases including Alzheimer disease (AD). In this study gross alteration of gene expression in AD mice by ibuprofen treatment is investigated via Protein-protein interaction network (PPI) analysis. Expression profiling of microarray dataset GSE67306 was retrieved from GEO dat...

Metastatic melanoma is an aggressive skin cancer and is one of the global malignancies with high mortality and morbidity. It is essential to identify and verify diagnostic biomarkers of early metastatic melanoma. Previous studies have systematically assessed protein biomarkers and mRNA-based expression characteristics. However, molecular markers for the early diagnosis of metastatic melanoma ha...

High-throughput gene profiling studies have been extensively conducted, searching for markers associated with cancer development and progression. In this study, we analyse cancer prognosis studies with right censored survival responses. With gene expression data, we adopt the weighted gene co-expression network analysis (WGCNA) to describe the interplay among genes. In network analysis, nodes r...