let g be a (p, q) graph. let k be an integer with 2 ≤ k ≤ p and f from v (g) to the set {1, 2, . . . , k} be a map. for each edge uv, assign the label |f(u) − f(v)|. the function f is called a k-difference cordial labeling of g if |νf (i) − vf (j)| ≤ 1 and |ef (0) − ef (1)| ≤ 1 where vf (x) denotes the number of vertices labelled with x (x ∈ {1, 2 . . . , k}), ef (1) and ef (0) respectively den...

The Escherichia coli clamp loader, c complex (c3dd’kc), catalyzes ATP-driven assembly of b clamps onto primer-template DNA (p/tDNA), enabling processive replication. The mechanism by which c complex targets p/tDNA for clamp assembly is not resolved. According to previous studies, charged/polar amino acids inside the clamp loader chamber interact with the double-stranded (ds) portion of p/tDNA. ...

Clamp loader proteins catalyze assembly of circular sliding clamps on DNA to enable processive DNA replication. During the reaction, the clamp loader binds primer-template DNA and positions it in the center of a clamp to form a topological link between the two. Clamp loaders are multi-protein complexes, such as the five protein Escherichia coli, Saccharomyces cerevisiae, and human clamp loaders...

Wheel/rail contact simulation is one of the most complicated problems in the modeling of railway vehicles. The wheel/rail interaction plays a unique role in rail vehicle dynamics. In this paper, the dynamic response of the wheel on irregular rail track is analyzed with analytical approach using the method of Multiple Scales (MMS). The Hertzian contact theory is used to obtain the relationshi...

This paper presents a comprehensive wheel model that can quantitatively evaluate traction performance of flexible/rigid wheels driving on deformable terrain. The proposed model exploits a terramechanics-based approach with taking account of pressures generated by wheel elasticity as well as terrain stiffness. Deflection of a flexible wheel typically depends on a relative pressure between the wh...

Wheel contour extraction from image is an important unit of any vision-based traffic accident analysis system, and automatically doing it is still a difficult task due to various distracting factors such as low contrast between the wheel and the ground, different wheel types and various weather conditions etc. In this work, a new automatic wheel extraction method is proposed, in which rather th...

Wheel out-of-roundness (OOR) inevitably jeopardizes the safety of railway operations. Regular visual inspection and checking by experienced workers are the commonly adopted practices to identify wheel defects. However, the defects may not be spotted in time. The paper puts forward a new method to real-time monitor wheel OOR based on PVDF strain sensor. Track strain response upon wheel-rail inte...

Molecular events in the clamp-loading reaction pathway of DNA replication are revealed by new crystal structures of bacteriophage T4 clamp loader-clamp-DNA complexes that capture two distinct conformations with the clamp open and closed.

DNA polymerases require tethering to an accessory factor, typically a ring-shaped clamp, to remain bound to DNA during replication. Three recent structural studies provide unique insight into how these clamps are loaded onto DNA by the clamp loader machinery.

rotary atomizers are commonly used in spray dryers to atomize feed. one destructive effect of wheel rotation is the creation of a vacuum inside the wheel that conducts hot air from the chamber into the wheel and can lead to atomizer blockage and an explosion. the present work determined the air-pumping characteristics of a rotary atomizer with a 50 mm wheel diameter. the vacuum pressure and pow...