Tear exchange beneath a contact lens facilitates ongoing fluid replenishment between the ocular surface and the lens. This exchange is considerably lower during the wear of soft lenses compared with rigid lenses. As a result, the accumulation of tear film debris and metabolic by-products between the cornea and a soft contact lens increases, potentially leading to complications. Lens design inno...

PURPOSE To compare the safety and efficacy of orthokeratology as a nonsurgical treatment for myopia in children with alternate methods, such as soft contact lenses, rigid gas permeable lenses, and spectacles, throughout multiple studies. DESIGN Perspective with literature review. METHODS Analysis of recent studies to determine the safety and effectiveness of orthokeratology versus soft cont...

BACKGROUND This is the first randomized, double-blind, placebo-controlled trial (EUDRACT No. 2009-013923-43) evaluating nickel oral hyposensitizing treatment (NiOHT) in patients with "systemic nickel allergy syndrome" (SNAS), characterized by Ni-allergic contact dermatitis and systemic reactions after eating Ni-rich food. METHODS Adults with positive Ni-patch test, who reported symptoms sugge...

OBJECTIVES The aim of this study was to measure tear film surface quality (TFSQ) using dynamic high-speed videokeratoscopy during short-term (8 hrs) use of rigid and soft contact lenses. METHODS A group of 14 subjects wore 3 different types of contact lenses on 3 different nonconsecutive days (order randomized) in 1 eye only. The subjects were screened to exclude those with dry eye. The lense...

Irritant or allergic contact dermatitis usually presents as an eczematous process, clinically characterized by erythematoedematovesicous lesions with intense itching in the acute phase. Such manifestations become erythematous-scaly as the condition progresses to the subacute phase and papular-hyperkeratotic in the chronic phase. Not infrequently, however, contact dermatitis presents with nonecz...

In 2013, we raised suspicion that cobalt in leather could be responsible for hitherto unrecognized cases of allergic contact dermatitis. We saw a patient sensitized only to cobalt with clear long-term exposure to cobalt from a leather sofa, and observed resolution of dermatitis following avoidance (1). In 2014,we performed a questionnaire study, which showed a positive and significant associati...

Contact inhibition refers to a reduction in the rate of cell migration and/or cell proliferation in regions of high cell density. Under normal conditions, contact inhibition is associated with the proper functioning tissues, whereas abnormal regulation of contact inhibition is associated with pathological conditions, such as tumor spreading. Unfortunately, standard mathematical modeling practic...

BACKGROUND Currently, cosmetic series (Chemotechnique Diagnostics, Sweden) is the most widely used cosmetic-related patch test in Korea. However, no studies have been conducted on how accurately it reflects the constituents of the cosmetics in Korea. OBJECTIVE We surveyed the constituents of various cosmetics and compare with the cosmetic series, to investigate whether it is accurate in deter...

BACKGROUND This study aimed to evaluate the adhesion of Acanthamoeba trophozoites on cosmetic contact lenses (CLs) with and without CL care multipurpose solution (MPS) treatment. METHODS Acanthamoeba lugdunensis L3a trophozoites were inoculated onto disks trimmed from CLs: 1-day Acuvue moist, 1-day Acuvue define, Acuvue 2, and Acuvue 2 define. After 18-hour inoculation, the number of adherent...