Acute heart failure (AHF) is the most common primary diagnosis for hospitalized heart diseases in Africa. As increased fatty acid β-oxidation (FAO) during heart failure triggers detrimental effects on the myocardium, we hypothesized that trimetazidine (TMZ) (partial FAO inhibitor) offers cardioprotection under normal and obese-related diabetic conditions. Hearts were isolated from 12-14-week-ol...

The development of insulin resistance in the obese individual could impair the ability to appropriately adjust metabolism to perturbations in energy balance. We investigated a 12- vs. 48-h fast on hepatic glucose production (R(a)), peripheral glucose uptake (R(d)), and skeletal muscle insulin signaling in lean and obese subjects. Healthy lean [n = 14; age = 28.0 +/- 1.4 yr; body mass index (BMI...

BACKGROUND Ultrasound is a non-invasive and readily available tool that can be prospectively applied at the bedside to assess muscle mass in clinical settings. The four-site protocol, which images two anatomical sites on each quadriceps, may be a viable bedside method, but its ability to predict musculature has not been compared against whole-body reference methods. Our primary objectives were ...

    Strategic programming, Complex supply chain, Lean, Production programming, Suppliers selection,   ELECTRE This paper represents a model of strategic programming with limited resources in a complex supply chain. The main goal of the proposed model is to increase efficiency and effectiveness of the supply chain with respect to income increases and cost decreases. Using special objective funct...

We recently demonstrated that in a rodent model of obesity (agouti yellow mice), there is a selective leptin resistance with preservation of the sympathetic actions despite loss of appetite and weight-reducing actions of systemic leptin. Here, we examined whether selective leptin resistance exists in agouti mice during central neural administration of leptin. In agouti obese mice and lean contr...

Inflammation and oxidative stress are believed to contribute to hypertension in obesity/diabetes. Recently, we reported a role for the AT(2) receptor in blood pressure control in obese Zucker rats. However, the role of AT(2) receptors in inflammation and oxidative stress in obesity is not known. Therefore, in the present study, we tested the effects of the AT(2) receptor agonist CGP-42112A on i...

We propose an effective and flexible scheme for reverse engineering of a Hamiltonian by designing the evolution operators to eliminate the terms of Hamiltonian which are hard to be realized in practice. Different from transitionless quantum driving (TQD), the present scheme is focus on only one or parts of moving states in a D-dimension (D ≥ 3) system. The numerical simulation shows that the pr...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 introduction: health care organizations have begun applying six sigma methods into their operations. on the other hand, the difficulty of using indicators to compare health care providers in a meaningful way has led to an increased focus on using information about “adverse events”- that is , events that should not happen i...

The efficacy of highly active antiretroviral therapy (HAART) has led to an increase demand for therapeutic use, thereby necessitating investigation into drug toxicity. This study was designed to investigate the in vivo effects of HAART on sperm parameters and testicular oxidative stress in lean and obese rats. Wistar rats (males, n = 40, weighing 180~200 g) were assigned randomly into 4 groups ...