This study examines strain differences in testosterone (T)-hydroxylations between Wistar and Dark Agouti (DA) rats of both genders. The DA rat, an animal model, is a poor metabolizer of such drugs as debrisoquine, which are metabolized by cytochrome P450 (CYP) 2D. T-16α-, 2α-hydroxylations, which are linked to CYP2C11, were catalyzed at similar rates by the microsomes of both strains. In contra...

BACKGROUND Type 2 diabetes has become the single most frequent cause of end-stage renal disease. The Goto-Kakizaki rat is currently used as a model for lean type 2 diabetes, but its renal changes have not been fully characterized. We investigated long-term functional and structural renal changes in the Goto-Kakizaki rat to evaluate if this animal model resembles the changes observed in human di...

Recent data have revealed biological and genetic variability in normotensive Wistar-Kyoto rats, which are considered to be the most appropriate control strain for spontaneously hypertensive rats. To investigate the possibility that angiotensin converting enzyme activity could be affected by this variability, we measured plasma and tissue (lung, heart, renal cortex, renal medulla, and adrenal gl...

tumor which would be transplantable in a non-inbred strain of rats as widely used as the Wistar strain, the authors have, in the course of the past several years, transplanted a number of spontaneous tu mors originating in Wistar rats. None of these transplants, however, survived the first passage. Recently, an adult Wistar rat with a spontane ous ascites tumor was brought to the attention of t...

Intracerebral inoculation of JHM virus (JHMV), the neuropathic strain of mouse hepatitis virus, into Wistar Furth, Wistar Lewis, and Fischer 344 rats at various ages indicated that Wistar Furth rats are more susceptible to the virus than are the other strains. Fischer 344 and Wistar Lewis rats were more resistant to inoculation at 2 and 5 days of age and completely resistant by 10 days of age. ...

Ethylene glycol (EG) exposure is a common model for kidney stones, because animals accumulate calcium oxalate monohydrate (COM) in kidneys. Wistar rats are more sensitive to EG than Fischer 344 (F344) rats, with greater COM deposition in kidneys. The mechanisms by which COM accumulates differently among strains are poorly understood. Urinary proteins inhibit COM adhesion to renal cells, which c...

Juvenile spontaneously hypertensive rats (SHR) have higher plasma levels of catechols and markedly larger catechol responses to yohimbine than do normotensive Wistar-Kyoto rats, indicating increased sympathoadrenal outflow and increased o^-adrenergic receptor-mediated restraint of peripheral catecholamine release during hypertension development in SHR. Yohimbine-induced catecholamine release an...

29 The Noda epileptic rat (NER), a Wistar colony mutant, spontaneously has tonic– 30 clonic convulsions with paroxysmal discharges. In the present study, we measured 31 phasic (I phasic) and tonic γ-aminobutyric acid A (GABA A) current (I tonic) in NER 32 hippocampal dentate gyrus granule cells (DGGCs) and compared the results with 33 those of normal parent strain Wistar rats (WIS).

Spontaneous chloroleukemia occurred in three adult members of a colony of Wistar rats. The chloroleukemia from one of these rats has been maintained in random-bred Wistar rats by inoculating tumor cells from leukemic donors into suckling rats. This report describes the course and manifestations, hematology, and pathologic changes of this transplantable chloroleukemia through ten serial subtrans...

The release of the neurotransmitter norepinephrine (NE) is modulated by presynaptic adenosine receptors. In the present study we investigated the effect of a partial activation of this feedback mechanism. We hypothesized that partial agonism would have differential effects on NE release in isolated hearts as well as on heart rate in vivo depending on the genetic background and baseline sympathe...