Abstract Burn injuries are a significant cause of death worldwide, leading to systemic inflammation, multiple organ failure and sepsis. The progression burn injury is explicitly correlated with mitochondrial homeostasis, which disrupted by the hyperinflammation induced injury, dysfunction cell death. Mitophagy plays crucial role in maintaining cellular homeostasis selectively removing damaged m...

PURPOSE We attempted to develop a device for measuring electrical corneal resistance (CR) using corneal contact lens electrodes to quantitatively evaluate corneal injury in vivo. In the present study, full-thickness detachment of the corneal epithelium was induced by n-heptanol, and the feasibility of the quantitative evaluation of this injury by corneal contact lens electrodes was evaluated in...

OBJECTIVES Cutaneous abscesses have traditionally been treated with incision and drainage (I&D) and left to heal by secondary closure. The objective was to compare the healing rates of cutaneous abscesses following I&D after primary or secondary closure. METHODS This was a randomized, controlled, trial, balanced by center, with blocked randomization created by a random-number generator. One u...

wound site plays an essential role in wound healing as these can contribute directly to vasculogenesis.This process is dysregulated in diabetic wounds. It has been shown that injury-induced Hoxa3 expression is impaired in diabetic mice and this affects the recruitment of cells to the wound. Restoration of Hox transcription factor results in a decrease in inflammatory cell (CD45+) and an increas...

Aims To identify the prevalence of neuropathic pain after lower limb fracture surgery, assess associations with severity, quality life and disability, determine baseline predictors chronic at three six months post-injury. Methods Secondary analysis a UK multicentre randomized controlled trial (Wound Healing in Surgery for Trauma; WHiST) dataset including adults aged 16 years or over following s...

Background: Platelets’ membranes are considered the paramount site for the assembly of tenase and prothrombinase complex and are key players in localising coagulation to wound sites. However, the endothelium is also known to express phosphatidylserine (PS) and support the binding of recombinant FVa/FXa even beyond the site of injury. It thus remain unclear, what cell type play the preeminent ro...

Severe thermal injury is associated with hypermetabolism and hypercatabolism, leading to skeletal muscle breakdown, lean body mass loss, weight loss, and negative nitrogen balance. Muscle protein catabolism in patients with severe thermal injury is the result of stress-induced increased release of cytokines and counterregulatory hormones. Coupled with decreased serum anabolic hormone concentrat...

The primary objectives of basic wound management center around promoting optimal wound healing and cosmesis. These objectives may be achieved through the systematic assessment, preparation, and repair of the laceration supplemented with appropriate patient care instructions. The meticulous and methodical management of traumatic wounds described in this article will assist the emergency physicia...

background: the aim of this study is to investigate the effect of vitamin a and c, as the agents that improve wound healing, on the adhesion formation process. materials and methods: sixty male wistar rats were used. they underwent midline laparotomy, for repair of a peritoneal injury, and were then assigned to four groups. group 1 (vitamin a) received 2000 units/kg intramuscular injection of v...